前列腺癌干细胞与雄激素受体信号通路的新进展
摘要
雄激素是维持前列腺生长和发育的重要激素,在前列腺相关疾病的病理生理中发挥着重要的作用。前列腺癌从激素依赖型转变为激素抵抗型前列腺癌的过程中,雄激素受体(androgen receptor,AR)一直是受关注的焦点,有观点认为,AR是前列腺癌出现从激素依赖型向激素抵抗型转变的关键分子。另有观点认为前列腺癌是从前列腺干细胞起源,并且,前列腺癌中含量极少的前列腺癌干细胞在前列腺癌激素剥夺治疗后复发和维持肿瘤生长过程中发挥了重要作用。这两种理论是否能够获得统一,还需进一步研究。
出处
《现代泌尿生殖肿瘤杂志》
2012年第6期355-357,共3页
Journal of Contemporary Urologic and Reproductive Oncology
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