模拟体液法快速合成羟基磷灰石纳米针及其吸附性能研究

Fast Preparation of Nano-sized Needle-like Hydroxyapatite in Simulated Body Fluid and Study on Its Adsorption Ability

采用模拟体液法快速制备羟基磷灰石(HA)纳米针,并研究了HA对牛血清蛋白质(BSA)的吸附性能。采用XRD、TEM、SEAD和FT-IR等分析方法表征样品。结果表明:1min即可快速制备宽约5nm,长为50～80nm且分散良好的HA纳米针,形貌和尺寸与人体中的HA极为相似;反应时间影响合成产物的形貌及物相,短时间内延长反应时间有利于HA纳米针的生长,但反应时间过长会导致HA再次反应生成Ca3(PO4)2;同时,快速制备的HA纳米针具有很强的吸附性能。

Ultrafine needle-like hydroxyapatite（HA） were fast prepared in simulated body fluid, and the adsorption ability toward bovine serum albumin（BSA） were studied. X-ray diffraction（XRD）, transmission electron microscopy（TEM）, selected area electron diffraction（SEAD） and Fourier transform infrared spectroscopy（FT-IR） were used to characterize the structure and morphology. The results show that well dispersed HA were synthesized for just one minute with about five nanometers in width, fifty to eighty nanometers in length. And the size and morphology of synthesized HA and those of HA in human bone are similar. The morphology and phase are influenced by the reaction time. It is useful of needle HA growing up with the time increased in a short period, but there will be Ca3 （PO4）2 generated in the solution if the reaction time is too long. The fast prepared nano-sized needle-like HA has the best adsorption ability toward BSA.