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石榴皮对抗STZ诱导的小鼠血糖升高作用研究 被引量:1

Pomegranate peel prevent high blood glucose induced by STZ
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摘要 目的:观察石榴皮提取物对链脲佐菌素诱导小鼠糖尿病的预防作用。方法:KM小鼠灌胃石榴皮乙酸乙酯提取物(Pomegranate Acetic ether Extract,PAE)3周后连续4次小剂量腹腔注射链脲佐菌素(STZ)诱导小鼠糖尿病,尾静脉取血测血糖,放免法检测血清胰岛素水平,制备石蜡切片光学显微镜观察胰腺组织病理学变化。结果:30 mg/kg PAE预防给药能对抗STZ引起的胰岛面积萎缩、空泡变,促进胰岛素分泌,显著对抗STZ诱导的血糖升高。结论:石榴皮乙酸乙酯提取物能预防STZ诱发的小鼠糖尿病。 To observe the preventive effects of pomegranate peel extract(PAE) on streptozotocin induced diabetes in mice. Methods: Repeated small dose streptozotocin was introperitoneally given to KM mice after PAE was lavaged for three weeks. The blood glucose was de- tected by blood glucose monitor,blood insulin level was determined by radioimmunoassay, and pathological change of pancreatic tissue was ob- served by optical microscope. Results: PAE can improve STZ induced atrophy and vacuolar degeneration in mouse pancreatic island, promote insulin secretion,has obviously antihyperglycemic effects on STZ induced diabetes. Conclusion: Pomegranate peel extract can prevent STZ induced diabetes in mice on a certain degree.
出处 《中药药理与临床》 CAS CSCD 北大核心 2012年第6期96-98,共3页 Pharmacology and Clinics of Chinese Materia Medica
基金 新疆维吾尔自治区自然科学基金(2012211A038) 新疆医科大学药理学重点学科青年启动基金
关键词 石榴皮 血糖 胰岛素 胰脏病理 Pomegranate peel blood glucose insulin pancreas pathology change
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