矽肺患者血清中甲状腺激素和白细胞介素-6的检测及其意义

Detection and significance of serum thyroid hormones and interleukin-6 in silicosis patients

目的探讨矽肺患者血清中甲状腺激素、白细胞介素-6水平的变化及其相互关系。方法 48例矽肺患者分别采用放射免疫法测定血清中总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、促甲状腺激素(TSH)及酶联免疫吸附法测定血清中白细胞介素-6(IL-6)水平,并以25例无任何疾病的健康检查者作对照。结果矽肺患者血清中TT3、TT4水平均显著低于对照组(P<0.01),血清中TSH水平均高于对照组,但差异无统计学意义(P>0.05)。矽肺Ⅱ期患者血清中TT3、TT4低于矽肺Ⅰ期,两者差异有统计学意义(P<0.05);矽肺Ⅲ期患者血清中TT3、TT4低于矽肺Ⅰ期,两者差异有统计学意义(P<0.01);而IL-6水平均显著高于对照组(P<0.01),Ⅰ、Ⅱ、Ⅲ期之间比较,血清中IL-6水平有随矽肺期别升高而升高的趋势,但差异无统计学意义。TT3、TT4与IL-6水平呈负相关(P<0.01)。结论血清TT3、TT4和IL-6水平反映了矽肺患者病情的严重性,检测血清中TT3、TT4和IL-6的浓度对判断病情及预后有一定意义。

[Objective]To study the changes of thyroid hormone and interleukin-6 level in serum of patients with silicosis and its correlation.[Methods]A total of 48 cases of silicosis patients were detected by radioimmunoassay for serum total three triiodothyronine（TT3）,serum total thyroxine（TT4） thyroid-stimulating hormone（TSH） and enzyme linked immunosorbent assay for serum interleukin-6 level（IL-6）,and 25 cases with no disease and health examination as control group.[Results] The TT-3,TT-4 in serum of patients with silicosis were significantly lower than those of control group（P0.01）,serum TSH was higher than that of control group,without significant difference（P0.05）.The serum TT-3,TT-4 of patients with silicosis stage II were higher than those of patients with silicosis stage I,with significant difference（P0.05）.The serum TT-3,TT-4 of patients with silicosis stage III were lower than those of patients with silicosis stage I,with significant difference（P0.01）,while the IL-6 was significantly higher than that of control group（P0.01）.The serum level of IL-6 was increased with rising stage of silicosis,but the difference was not significant.TT-3,TT-4levels were negatively correlated with the level of IL-6（P0.01）.[Conclusion] Serum TT-3,TT-4 and IL-6 levels reflect the severity of illness in patients with silicosis,detection of serum TT-3,TT-4 and IL-6 concentration had significance on the judgment of severity and prognosis.