丙型肝炎病毒感染与2型糖尿病发病关系的研究

The association between hepatitis c virus infection and type 2 diabetes

目的通过调查2型糖尿病患者中丙型肝炎病毒抗体(抗-HCV)的流行情况,探索HCV感染是否为2型糖尿病发病的危险因素。方法采用酶联免疫法(ELISA)对710例2型糖尿病患者与696例非糖尿病者(对照组)的血清进行抗-HCV检测,并进行比较。结果 2型糖尿病组的抗-HCV阳性率(3.10%)明显高于对照组的阳性率(1.29%),两者比较差异有统计学意义(χ2=5.313,P<0.05)。但在所有年龄组中,只有60～69岁年龄组中两者比较差异有统计学意义(χ2=6.891,P<0.01)。2型糖尿病组与对照组之间比值比(OR)为2.44(95%CI1.14-5.21)。结论 HCV感染可能是2型糖尿病发病的危险因素之一。

Objective The risk of diabetes was studied through the investigation of the prevalence of anti-hepatitis C virus antibody （anti-HCV） in the patients with type 2 diabetes. Methods 710 cases of type 2 diabetes and 696 cases of control subjects were included in this study. Enzyme-linked immunosorbent assay （ELISA） was used in the determination of anti-HCV antibody. Results The anti-HCV positive rate in the type 2 diabetes group （3.10%） was significantly higher than the control group （1.29%） （χ2=5.313,P〈 0.05）. Significant difference was also observed in the age group of 60-69 （χ2=6.891,P〈 0.01）. The odds ratio（OR） in type 2 diabetes group and eontrol group was 1.44 （95% CI 1.14-5.21）. Conclusion HCV may be one of the risk factors for type 2 diabetes.