食管癌患者的血清白细胞介素和急性时相反应蛋白含量变化研究

A Study on the Changes of Serum Cytokine and Acute Phase Reaction Protein in Patients with Esophageal Cancer

目的:探讨食管癌患者的血清白细胞介素和急性时相反应蛋白的含量变化及其临床意义。方法:选择食管癌患者46例作为观察组,其中早期(Ⅰ～Ⅱ)食管癌患者25例、晚期(Ⅲ～Ⅳ)食管癌患者21例,测定患者的血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)和急性时相反应蛋白中的C反应蛋白(CRP)、转铁蛋白(TRF)、前清蛋白(PAB),以健康体检合格人群42例作为对照组,分析食管癌患者的血清白细胞介素和急性时相反应蛋白的含量变化特点。结果:与对照组比较,观察组血清IL-6、IL-8水平均明显增高(P<0.05),TNM分期(Ⅲ+Ⅳ)食管癌患者升高更为明显(P<0.05);与对照组比较,观察组血清CRP水平明显增高(P<0.05),TRF、PAB水平明显降低(P<0.05),TNM分期(Ⅲ+Ⅳ)食管癌患者变化更为明显(P<0.05)。结论:食管癌患者的血清白细胞介素和急性时相反应蛋白含量变化能够反映病情变化,有助于食管癌的临床诊断。

Objective： To discuss the changes of serum Cytokine and Acute Phase Reaction Protein in patients with esophageal cancer and its clinical significance.Methods： Forty-six patients with esophageal cancer were selected as the observation group,including of 25 casesofearly（I-II）esophageal cancerand 21 casesofadvanced（IIItoIV）esophagealcancer.Thelevelsof serum Cytokine（IL-6,IL-8） and acute Phase Reaction Protein（CRP,TRF,PAB） were detected.Forty-two healthy peoples were treated as the control group.Results： Compared with the control group,the levels of serum IL-6,IL-8 in observation group was significantly higher（P0.05）,and the patients in TNM stage（III＋IV） increased much more（P0.05）.Compared with the control group,the serum CRP levels of observation group was significantlyhigher（P0.05）,the TRFand PAB levels were decreased significantly（P0.05）,and patients in TNM stage（III＋IV） changed more significantly（P0.05）.Conclusions： The changes and clinical significance of serum Cytokine and Acute Phase Reaction Protein in patients with esophageal cancer can reflect the functional status,it is helpful to the clinical diagnosis of esophageal cancer.