摘要
目的探讨慢性丙型肝炎(chronic hepatitis C,CHC)并脂肪肝(fatty liver,FL)血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平与病毒和代谢因素的相关性。方法选择118例初次就诊且未行抗病毒治疗的CHC,根据是否伴FL分为FL组55例和非FL组63例。检测两组A-FABP水平,并比较其水平与丙型肝炎病毒、血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、体重指数(BMI)、空腹血糖(FPG)、胰岛素水平(FINS)、甘油三酯(TG)、胆固醇(CHO)及胰岛素抵抗指数(HO-MA-IR)等的相关性。结果 FL组TG较非FL组明显升高,FINS、HOMA-IR及A-FABP血清水平明显低于非FL组(P<0.05)。相关性及回归分析表明,A-FABP同BMI、FPG、FINS、HOMA-IR明显呈正相关,并且同TG水平明显负相关,FINS是A-FABP水平的独立相关因素(r2=0.830,P<0.01)。结论 CHC并发FL与患者血清A-FABP水平下降密切相关,与病毒因素不相关,且FINS是此类患者A-FABP水平变化的独立相关因素。
Objective To investigate the viral and metabolic factors associated with serum level of adipocyte type fatty acid binding protein （A-FABP） in patients with chronic hepatitis C （CHC） complicated with fatty fiver （FL）. Methods A total of 118 patients who were not treated with CHC at the first visit in our hospital were divided into two groups according to diagnosis combined with FL： 55 patients combined with FL in group A and 63 patients without FL in group B. The levels of A-FABP of the two groups were detected and the correlated comparison was made with Hepatitis C virus, serum alanine transaminase （ALT）, aspartate trans- aminase （AST）, body mass index （BMI）, fasting plasma glucose （FPG）, Fasting insulin （FINS）, triglyceride （TG）, cholesterol （CHO） and insulin resistance index （HOMA-IR）. Results The TG of group A was significantly higher than that of group B, and FINS, HOMA-IR and the level of A-FABP of group A were significantly lower than those of group B （P 〈 0. 05）. Partial correlation analysis showed that serum A-FABP was positively correlated to BMI, FPG, FINS and HOMA-IR, and negatively correlated to TG. Multiple linear regressions showed that FINS was independent variables of serum A-FABP （ r2 = 0. 830, P 〈 0. 01 ）. Conclusion The catabatic level of serum A-FABP is closely correlated with patients CHC and FL, and not correlated to viruses factors. The FINS is independent variables of serum A-FABP of patients with CHC and FL.
出处
《临床误诊误治》
2013年第2期68-71,共4页
Clinical Misdiagnosis & Mistherapy
基金
国家自然科学基金(30600524)
