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雷公藤多苷治疗儿童肾病综合征的机制探讨 被引量:2

Application of Tripterygium Wilfordii Hook on nephrotic syndrome in children and its mechanism study
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摘要 目的 :探讨雷公藤多苷在治疗儿童肾病综合征中的作用及其机制。 方法 :对 16年来在我科住院明确病理类型的 5 5 0例中 10 5例肾病综合征患儿 ,在激素逐渐减量的同时用雷公藤多苷 ( 1m g/ kg· d- 1 )治疗。 结果 :81例肾病综合征获得缓解 ,总缓解率达 77.1% ,其中 MCNS( 2 4例 )、Ms PGN ( 46例 )、MPGN ( 17例 )、MN ( 13例 )和FSGS( 5例 )的缓解率分别为 91.7%、89.1%、76 .5 %、38.5 %和 0 % ,FSGS效果最差 ;14例改善 ,10例无效。 结论 :由于病理类型不同疗效相差较大 ,临床上对激素治疗无效或耐药的肾病综合征患儿 ,应及时行肾活检以明确病理诊断 ,对病理类型为 MCNS和 Ms PGN者可单用雷公藤多苷治疗 ,以避免长期应用激素的不良反应 。 s: Objectives:To understand the therapeutical effect of Tripterygium Wilfordii Hook on children with nephrotic syndrome and its mechanism. Methods:Tripterygium Wilfordii Hook at a dose of 1 mg/(kg·d) were given to every patient during prednison were withdrown.These patients,in the total 85 cases,were choosen from 550 children with glomerulonephritis diagnosed by renal pathology since last ten years. Results: Entire remission occured in 105 cases and its rate reached 77.1%,among them 24 were in MCNS( 94. 1%) , 31 MsPGN(88.6%),11 MPGN( 73.3 %),5 MN(38.5%),respectively. Twelve patient's condition were improved, ten patients were no effective. Conclusions: The therapeutical effects of Tripterygium Wilfordii Hook is various with renal histologic changes. The patients which are steroid resistant or frequent relapse should be done renal biopsy to establish its histologic diagnosis.For MCNS and MsPGN, Tripterygium Wilfordii Hook can be used alone to get good results and to avoid sideeffects of steroids applied consecutively.
出处 《医学研究生学报》 CAS 2000年第B05期9-11,共3页 Journal of Medical Postgraduates
关键词 雷公藤多苷 儿童 肾病综合征 病理 Tripterygium Wilfordii Hook Children Nephrotic syndrome Pathology
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  • 1郑家润,中国医学科学院学报,1987年,9卷,5期,323页
  • 2郑家润,中国医学科学院学报,1985年,7卷,1期,1页
  • 3张乃峥,中华内科杂志,1984年,23卷,19期,593页
  • 4郑家润,中医杂志,1982年,9期,75页

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