摘要
An unprecedented decarboxylative alkylation reaction of fl-keto acids with isochromans has been developed under oxidative conditions. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity.
An unprecedented decarboxylative alkylation reaction of fl-keto acids with isochromans has been developed under oxidative conditions. A range of β-keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6-tetramethylpiperdine-1-oxoammonium hexafluorophosphate to give structurally diverse 1-acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity.
基金
Acknowledgement We are grateful for the financial support from the National Natural Science Foundation of China （21232007 and 21172206）, the National Basic Research Program of China （973 Program 2010CB833300）, and the Program for Changjiang Scholars and Innovative Research Team in University （IRT1189）.
