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CD11/CD18在脑缺血再灌注损伤中的作用 被引量:4

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摘要 粘附分子CD11 CD18是在白细胞上表达的糖蛋白 ,缺血 再灌注损伤时的作用是介导白细胞与内皮细胞的粘附及渗出到缺血组织 ,缺血性卒中患者和脑缺血动物模型中均发现其表达升高。通过降低CD11 CD18可以减少脑梗死的体积和白细胞在缺血组织中的数量 ,有望成为治疗缺血性卒中的一种方法。
作者 夏斌 邵福源
出处 《国外医学(脑血管疾病分册)》 2000年第3期134-136,共3页 Foreign Medical Sciences Cerebrovascular Diseases
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参考文献10

  • 1Lee DH,Tam SS,Wang E,et al.The NF-κB inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11bCD18 and CD106[].Immunology Letters.1996
  • 2Banda MA,Lefer DJ,Granger DN.Postischemic endothelium-dependent vascular reactivity is preserved in adhesion molecule-deficient mice[].American Journal of Physiology.1997
  • 3Soriano SG,Coxon A,Wang YF,et al.Mice deficient in Mac-1(CD11bCD18) are less susceptible to cerebral ischemia reperfusion injury[].Stroke.1999
  • 4Kato H,Kogure K,Liu XH,et al.Progressive expression of immunomolecules on activated microglia and invading leukocytes following focal cerebral ischemia in the rat[].Brain Research.1996
  • 5Fiszer U,Korczak-Kowalska G,Palasik W,et al.Increased expression of adhesion molecule CD18(LFA-1 beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke[].Acta Neurologica Scandinavica.1998
  • 6Filep JG,Delalandre A,Payette Y,et al.Glucocorticoid receptor regulates expression of L-selectin and CD11 CD18 on human neutrophils[].Circulation.1997
  • 7Gidday JM,Park TS,Gonzales ER,et al.CD18-dependent leukocyte adherence and vascular injury in pig cerebral circulation after ischemia[].American Journal of Physiology.1997
  • 8Prestigiacomo CJ,Kim SC,Connolly ES Jr,et al.CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke[].Stroke.1999
  • 9Fabian RH,Kent TA.Superoxide anion production during reperfusion is reduced by an antineutrophil antibody after prolonged cerebral ischemia[].Free Radical Biology and Medicine.1999
  • 10Yenari MA,Kunis D,Sun GH,et al.Hu23F2G, an antibody recognizing the leukocyte CD11 CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia[].Experimental Neurology.1998

同被引文献25

  • 1郝延磊,蒲传强,朱克,张凤英,刘洁晓.细胞间粘附分子-1和E-选择素在局部脑缺血中的作用[J].中华老年心脑血管病杂志,2000,2(1):54-57. 被引量:16
  • 2脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381-383. 被引量:15757
  • 3Kawaharada M, Urasawaa K. Immunological functions and clinical course of elderly patients with cerebrovasular diseases, Nippon Rohen Igakkai Zasshi, 1992; 29(9) :652 - 660.
  • 4Carlos TM, Harlan J-M. Leukocyte -endothelial adhesion molecules. Blood, 1994;84(7) :2068- 2071.
  • 5Garcia JH, Liu KF, Bree MP. Effects of CD11b/CD18 monoclonal antibody on rats with permanent middle cerebral artery occlusion.Am J pathol, 1996; 148(1):241-248.
  • 6Nath FP, Kelly PT, Jenkins A, et al. Effects of experimental intracerebral hemorrhage on blood flow, capillary permeability, and histochemistry. J Neurosurg, 1987;66(4) :555 - 562.
  • 7Yang GY, Betz AL, Chenevert TL, et al.Experimental intracerebral hemorrhage: relationship between brain edema, blood flow and blood brain barrier permeability in rats. J Neurosurg, 1994; 81 (1) :93 - 102.
  • 8Lowe GDO, Pavelec RS, Peterson MA, et al. Relation of atriol fibrillation and high hametocrit to mortality in acute stroke[J ]. Lancet, 1983, 1:784
  • 9Akoppv SE, Simonian NA, Grigorian GS. Dynamics of polymorphonuclear leukocytes accumulation in acute cerebral infarction and their correlation with brain tissue damage[J] .Stroke, 1996, 27: 1739
  • 10Elneihoum AM, Falke P, Axelsson L, et al. Leukocyte activation detected by increased plasma levels of inflammatory mediaters in patients with ischemic cerebrovascular disease[J ] .Stroke, 1996, 27:1734

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