西洛他唑致药物热1例

One case of drug fever induced by cilostazol

1例78岁老年男性，既往有糖尿病病史20余年，因双下肢麻木四月余入院。B超与cT检查结果均提示下肢动脉重度闭塞，予盐酸沙格雷酯片0．1gtid联合西洛他唑片100mgbid治疗。联合用药1d后，患者出现发热，体温升高至37．9℃。采用冰袋物理降温及予甲磺酸左氧氟沙星片抗感染治疗5d，体温波动于36．8～37．7℃。期间查血常规、胸片，结果提示感染可能性不大，考虑可能与药品相关。第六天停用与出现发热有时间关系的盐酸沙格雷酯片与西洛他唑片，第七天患者体温恢复至36．0～36．5℃，第八天患者再次服用西洛他唑片50mg后，体温再次升高至37．3℃，16h后体温降至正常。

One 78-year-old male patient with diabetes for over 20 years was admitted to hospital due to numbness of lower limbs. Results of type-B ultrasonic and CT revealed severe arterial occlusion of lower limbs. Cilostazol tablets and sarpogrelate hydrochloride tablets were administered orally. The body temperature of the patient increased from 35.0 - 36.5 ℃ to 37.9 ℃.One day after combination therapy, the body temperature fluctuated from 36.8 ℃ to 37.7 ~ after the physical cooling of ice packs and anti- infection treatment of mesylate levofloxacin tablets for 5 days. The results of blood routine examination and chest X-ray revealed no infection indicators, so cilostazol tablets and sarpogrelate hydrochloride tablets assiociated with the fever were stopped at the sixth day. The patient＇s temperature returned to 36.0 - 36.5 ℃ on the seventh day. When the cilostazol tablet was given once more, the patient＇s temperature increased to 37.3 ℃ and returned to normal 16 hours later.