4-氨基苯甲酸的合成工艺研究

Synthesis of 4-amino benzoic acid

以苯胺为原料,经酰基化、碘仿两步反应合成得到了目标产物4-氨基苯甲酸,并采用IR、1H NMR和13C NMR对产物结构进行了表征;探讨酰基化反应时催化剂AlCl3的用量、反应温度及反应时间对中间体4-氨基苯乙酮产率的影响,以及碘仿反应中反应温度、反应时间和滴加4-氨基苯乙酮速率对产物产率的影响.在此合成条件下,4-氨基苯甲酸的产率为94.0%,纯度99.7%.

With aniline as raw material, through acylation and iodoform reactions, the target compound 4-amino benzoic acid was synthesized and characterized by IR, ^1H NMR and ^13C NMR. In the acylation reaction, the influences of dosage of catalyst AlCl3, reaction temperature and reaction time on the yield of intermediate 4-amino acetophenone were investigated. In the iodoform reaction, the influences of reaction temperature, reaction time and dropping speed of 4-amino acetophenone on the yield of 4-amino benzoic acid were investigated. Under the optimal conditions, the yield of 4-amino benzoic acid was 94.0% with purity of 99.7%.