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解酒护肝饮对酒精性肝损伤大鼠血清和肝组织ALT、AST的影响 被引量:50

The effect of relieving alcoholism and protecting liver drink on the blood serum,liver tissue ALT and AST of alcoholic liver injury rat
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摘要 目的 通过观察解酒护肝饮对酒精性肝损伤大鼠血清和肝组织 ALT、AST的影响 ,验证其对酒精性肝损伤的防治作用及药效。方法 以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,分别预防给药和治疗给药后检测各组大鼠血清和肝组织 ALT、AST含量。结果 预防给药结果表明 :解酒护肝饮高剂量降低模型大鼠血清 ALT作用优于益肝灵 ,降低肝组织 ALT作用优于葛花解酲汤。高、低剂量降低血清 AST作用与葛花解酲汤、益肝灵相当 ,但降低肝组织 AST作用均优于两对照药。高、低剂量具有量效关系。治疗给药结果表明 :解酒护肝饮高、低剂量均能降低模型大鼠血清及肝组织 ALT、AST,作用与益肝灵、葛花解酲汤相当。高、低剂量具有量效关系。结论 解酒护肝饮通过保护肝细胞 ,抑制肝组织内 ALT、AST的升高 ,并能稳定肝细胞膜 ,抑制 ALT、AST释放入血 ,可有效防治酒精性肝损伤 ,且疗效优于益肝灵与葛花解酲汤。 Objective To observe the effectofrelieving alcoholism &protecting liver drink on alcoholic liver injury of rat's blood serum,liver tissue ALT and AST as well as test its phar- macological effectand function mechanism.Methods The ratmodel of alcoholic liverinjury was duplicated by filling the stomach with white spirit and then was given prevention medicine and treatment medicine respectively,and the ALT and AST or rat's blood serum,liver tissue of in each group were determined,and Yi ganling as well as decoction of pueravia flower were used as comparison.Results The result of prevention medicine suggested that the high- dose drink of relieving alcoholism &protecting liver appeared more significant function in reducing rat's blood serum ALT than Yi ganling,more significant function in reducing liver tissue AST than decoc- tion of pueravia flower,whereas the drink of high or low dose appeared similar function in reduc- ing blood serum AST with decoction of pueravia flower and Yi ganling but manifested better function in reducing liver tissue AST than the two control groups.Thus we conclude thatdose- effectrelationship existed between high or low dose drink ofrelieving alcoholism &protecting liv- er.Conclusions The drink of relieving alcoholism &protecting liver could inhibit the elevation of ALT and AST in the liver tissue by protecting liver cells ,stablize the liver cells membrane, inhibit the resolve of ALT and AST into blood and effectively prevent alcoholic liver injury and had better curative effect than Yi ganling and decoction of pueravia flower
出处 《河北中医》 2000年第10期793-796,共4页 Hebei Journal of Traditional Chinese Medicine
基金 河北省卫生厅资助!项目 (编号 990 2 5 )
关键词 酒精性肝损伤 解酒护肝饮 ALT AST 中医药疗法 alcoholic liver injury,drink of relieving alcoholism &protecting liver,preven- tion,ALT,AST
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  • 1W. K. Lelbach. Liver cell necrosis in rats after prolonged ethanol ingestion under the influence of an alcohol-dehydrogenase inhibitor[J] 1969,Experientia(8):816~818

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