影响进展期胃癌根治术预后的多因素分析

Multivariate Analysis of Prognosis Related Risk Factors for Advanced Gastric Carcinoma by Radical Surgery

目的探讨影响进展期胃癌根治术预后的相关危险因素,为临床防治提供参考。方法回顾性分析作者医院2003-07/2007-07月期间收治的152例患者行胃癌根治术的临床资料,对所有患者进行跟踪随访。生存率采用Kaplan-Meier分析法,率的比较采用χ2检验,对有统计意义的单因素进行多因素非条件的logistic回归分析。结果单因素分析结果显示,有无淋巴结转移,TNM分期,肿瘤大小、分化程度、浸润深度、淋巴结清扫范围、术后并发症及大体分型与进展期胃癌根治术的预后相关(P<0.05)。多因素非条件的logistic回归分析显示,有无淋巴结转移,TNM分期、分化程度、浸润深度和淋巴结清扫范围是影响胃癌根治术后预后的相对独立危险因素(P<0.05)。结论有无淋巴结转移,TNM分期、分化程度、浸润深度和淋巴结清扫范围是影响胃癌根治术后预后的相对独立危险因素。

Objective To explore the prognosis related risk factors for patients with advanced gastric carcinoma by radical surgery and provide reference for clinic.Methods The materials of 152 patients with advanced gastric carcinoma by radical surgery from July 2003 to July 2007 were retrospective analyzed.The patients were followed up.Kaplan-Meier survival analysis method was adopted.The the rates was compared by chi-square test.Multivariate unconditional logistic regression analysis was performed to test the significant factors.Results Univaritae analysis results showed that the prognosis for adanced gastric cancer was closely related to lymph node metastasis,TNM stage,tumor size,differentiation degree,infiltration depth,lymph node cleaning scope,the postoperative complications and general parting（P0.05）.Mulitvairate logistic regression showed that lymph node metastasis,TNM stage,differentiation degree,infiltration depth and lymph node cleaning scope were the independent risk factors（P0.05）.Conclusion Lymph node metastasis,TNM stage,differentiation degree,infiltration depth and lymph node cleaning scope are the risk factors for patients with advanced gastric carcinoma by radical surgery.