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基因工程大鼠研究进展 被引量：12

Progress in research of rat genetic engineering
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摘要 相对小鼠而言,大鼠在生理、行为、代谢等方面更接近人类。近年随着基因工程大鼠技术的开发,大鼠开始回归于生命科学实验和医药研究,基因工程大鼠的研究成为实验动物科学的热点。目前适用于大鼠基因工程的技术各有优缺点。本文对大鼠转基因技术,转座子技术,ZFN锌指酶技术,TALENs技术和基于胚胎干细胞的基因打靶技术的研究进展做了比较。 The characteristics of physiology, behavior and metabolism in rats are more close To those of human beings than those of mice. With the development of rat genetic engineering techniques in recent years, the genetically modified rats have been a hot point of laboratory animal science, and rats retake the center stage of life science and pharmaceutical research. The advantages, disadvantages and research progress of the transgene, transposon, ZFN （zinc finger enzymes ）, TALENs and embryonic stem cell-based gene targeting are compared in this review paper.
作者 王贵利 张连峰
机构地区 中国医学科学院医学实验动物研究所
出处 《中国比较医学杂志》 CAS 2013年第3期71-76,共6页 Chinese Journal of Comparative Medicine
基金 国家科技支撑计划课题(2012BAI39B02) 国家“重大新药创制”科技重大专项课题(2011ZX09307-302)
关键词 大鼠 转基因 转座子 锌指酶 TALENs Rat Transgenic Transposon ZFN TALENs
分类号 Q95-33 [生物学—动物学] R349.83 [医药卫生—基础医学]
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共引文献6

同被引文献209

引证文献12

二级引证文献43

中国比较医学杂志
2013年 第3期

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