青少年卵巢恶性肿瘤临床特点及预后分析

Analysis of the clinical characteristics and prognosis ofyoung people malignant ovarian neoplasm

目的 :了解青少年卵巢恶性肿瘤临床特点及预后的关系。方法 :收集本院1985年～1994年间治疗的20岁以下青少年卵巢恶性肿瘤28例 ,并作了5年的跟踪随访。结果 :本组青少年卵巢恶性肿瘤中生殖细胞肿瘤24例(85.71%) ,上皮性肿瘤3例(10.71 %) ,性索间质肿瘤1例(3.57 %)。10例采用保留生育功能手术 ,其中3例治疗后正常分娩 ,6例采用卵巢癌根治术 ,10例采用肿瘤细胞减灭术 ,5年生存率分别为60 %、50 %、0%。术后24例患者辅以化疗 ,使用VAC方案6例 ,用BEP或BVP方案18例 ,5年生存率分别为16.67%、50%。结论 :对青少年卵巢恶性肿瘤应尽可能采用保留生育功能手术 ,恶性生殖细胞肿瘤术后最好采用BEP/BVP方案化疗6疗程 ,可明显改善预后。

Objective:To learn about the relationship between clinical characteristics and prognosis of young people ovarian carcinoma.Methods:28 cases of young people ovarian carcinoma who were less than 20_years old from 1985 to 1994 were collected in this study,and 5_year follow-up was done.Results:There were 24 cases of malignant germ cell neoplasm (85.71%),3 cases of epithelial ovarian carcinoma (10.71%),only one case of sex cord stromal tumor(3.57%).All patients underwent operation and chemotherapy.Main operation types were preserving pregnancy ability (10 cases,of wihich 3 had normal term labor after operation),radical operation(6 cases),and tumor volume recessive operation(10 cases).Their 5-year survival rates were 60%,50%,0% respectively.24 patients underwent abjuvant chemotherapy.6 patients had VAC regimen and 18 patients received BEP/BVP regimen.Their 5-year survival rates were 16.67% and 50% respectively.Conclusion:We should try our best to preserve the pregnancy ability of young people with ovarian carcinoma in the operation.As for malignant germ cell neoplasm,6 courses of BEP/BVP chemotherapy after operation is necessary for good prognosis.