吡喹酮、阿苯达唑治疗大鼠异盘肺吸虫病的毒性反应与效果比较

Comparative Studies Between the Effects and Sideeffects of Praziquantel & Albendazole on the Paragonimiasis Heterotremus in Rats

目的 :直接比较吡喹酮和阿苯达唑治疗大鼠异盘肺吸虫病的效果和毒性反应。方法 :吡喹酮和阿苯达唑均按1 0 0 mg·kg- 1 · d- 1 ,连用 2 d,间隔 2 4h灌胃治疗粪检阴性的 Wistar大鼠各 1 0只 ,并设正常对照。其后观察动物毒性反应 ,于 2次用药后第 5 d剖杀动物 ,收集各部位虫体 ,用解剖镜观察、记录各鼠活虫回收数。结果 :吡喹酮组无 1例出现反应 ,阿苯达唑组反应明显 ,阿苯达唑组与吡喹酮组反应率有显著性差异 (P<0 .0 5 )。解剖镜下见吡喹酮组虫体损害较阿苯达唑组明显严重。吡喹酮组与阿苯达唑组平均活虫回收率分别为 1 2 .5 % ,33.75 % ,两组比较有显著性差异(q=3.91 ,P<0 .0 5 )。结论 :吡喹酮与阿苯达唑同剂量治疗大鼠异盘肺吸虫病 。

Purpose:Directly compare the effects with side effects of praziquantel and albendazole on the Paragonimiasis heterotremus in rats.Methods:With praziquantel and albendazole at 100mg·kg -1 ·d -1 ×2,every 24h,gastrogavage 10 rats respectively,which had not been infected Paragomimus.Then set the control and observed the side effects.At the 5d after giving drugs the second time,we killed the rats,collected the worms in the animals,and observed the worms with an anatomy microscope.All the living worms number could be recorded.Ruselts:No side effect occurred in the praziquantel group,but remarkable side effect in the albendazole group occurred.There was a significant difference in side effect rates between the albendazole and praziquantel ( P <0.05).Under the anatomy microscope,the worm body damaging of the praziquantel group was more serious than that of the albendazole group.The living worm average collected rates of the praziquantel and albendazole were 12.75% and 33.75%,respectively.There was a significant difference in effects between the two groups statistically (q=3.91, P <0.05).Conclusion:Praziquantel is more effective and less side effect than albendazole when the two drugs treat the Paragonimiasis heterotremus with the same dose.