肠易激综合征中医证候规律的研究

Factor Analysis and Cluster Analysis of the TCM Pattern of Irritable Bowel Pattern

目的:研究肠易激综合征(IBS)的中医证型分布规律。方法:对309肠易激综合征患者进行中医临床流行病学调查,提出症状、舌象、脉象,运用聚类分析法对130个变量进行分析。结果:分为肝郁脾虚、脾肾阳虚、肝阳上亢、湿邪中阻、肝气郁滞、肝气乘脾、脾胃虚弱、大肠湿热、脾胃气滞等9个证型。结论:IBS病位在大肠但证型分布紧紧围绕肝和脾胃,并与湿邪密切相关,主要证素有肝实、脾虚、湿热、寒湿等,病性多虚实错杂;所得证型与中医理论和临床契合,可为临床提供一些较为客观的诊断和治疗依据。

Objective：To research the TCM pattern of irritable bowel pattern （IBS）. Methods： We extracted data of symptoms, tongue manifestation and pulse condition from TCM epidemiology research of 309 cases of IBS, then used the factor analysis and cluster analysis on 88 variables. Results： It broken down to 12 TCM patterns, i.e. pattern of liver depression and spleen deficiency, pattern of liver qi invading the Stomach, pattern of dual deficiency of the heart and spleen , spleen-kidney yang deficiency pattern, pattern of ascendant hyperactivity of liver yang , pattern of depressed gallbladder with harassing phlegm, spleen deficiency pattern , pattern of liver depression and qi stagnation , liver qi invading the spleen, pattern of dampness-heat in the spleen and stomach, large intestinal dampness-heat pattern, qi stagnation of the spleen and stomach. Conclusion： The research reflects the potential factors which determines the correlation between the variables, and provides some objective clinical diagnosis and treatment basis.