碘染色诊断早期食管癌及癌前病变的临床研究

Clinical research on iodine staining for diagnosis of early esophageal cancer and precancerous lesions

目的探讨内镜下碘染色在诊断早期食管癌及癌前病变的作用和应用价值。方法用1.2%碘液10 mL对射洪县仁和镇2 046例40～69岁人群进行内镜下食管黏膜染色,视染色情况进行活组织病理检查。结果通过染色确定行食管活检147例。经病理检查证实,7例为食管正常黏膜,95例为食管黏膜慢性炎症,14例为轻度不典型增生,14例为中度不典型增生,6例为重度不典型增生,2例为黏膜内癌,1例为黏膜下癌,8例为浸润癌。结论内镜下碘染色对早期食管癌及癌前病变的早期诊断简便易行,推动了食管癌的防治进程,是高发区筛查人群早期食管癌及癌前病变早期诊断的有效手段。

Objective To investigate the effect and application value of the endoscopic iodine staining in the diagnosis of early esophageal cancer and precancerous lesions.Methods 2 046 people aged 40-69 years old from Renhe town of Shehong County were performed the endoscopic esophageal mucosa staining with 1.2% iodine solution 10 mL,taken biopsy for living tissure pathological examination according to the dyeing condition.Results 147 cases were taken esophageal biopsy determined by the staining.By pathological examination,7 cases were confirmed to be normal esophageal mucosa,95 cases were chronic esophagitis,14 cases were mild dysplasia,14 cases were moderate dysplasia,6 cases were severe dysplasia,2 cases were intramucosal carcinoma,1 case was submucosal carcinoma and 8 cases were invasive carcinoma.Conclusion Endoscopic iodine staining is simple for diagnosing early esophageal cancer and precancerous lesions,promotes the progress of esophageal cancer prevention and control,and is an effective method widely used in population screening in the high incidence area for early diagnosing esophageal carcinoma and precancerous lesions in the early stage.