盐酸吡柔比星与丝裂霉素交替膀胱灌注对腺性膀胱炎术后复发及生活质量的影响

Effects of pirarubicin hydrochloride and mitomycin alternate intravesical instillation on quality of life and recurrence after operation of cystitis glandularis

目的研究盐酸吡柔比星与丝裂霉素交替膀胱灌注对腺性膀胱炎术后复发及生活质量的影响。方法 60例腺性膀胱炎患者手术后随机分为观察组及对照组。对照组:采用盐酸吡柔比星膀胱灌注。观察组:采用盐酸吡柔比星与丝裂霉素交替膀胱灌注。结果观察组和对照组的灌注方法疗效比较,差异无统计学意义(P>0.05)。治疗后,观察组在躯体功能及心理功能等两个方面优于对照组,差异均有统计学意义(P<0.05)。治疗期间,观察组总不良反应率16.67%低于对照组总不良反应率40.00%,差异有统计学意义(P<0.05)。结论盐酸吡柔比星与丝裂霉素交替膀胱灌注预防腺性膀胱炎术后复发疗效可靠,患者生活质量较高,而且不良反应也轻,安全性更好。

Objective To study of pirarubicin hydrochloride and mitomycin alternate intravesical instillation of interntion on quality of life and recurrence after operation of cystitis glandularis, Methods After operation ,60 cases of cystitis glandularis patients were randomly divided into the observation group and control group. The control group ： using intravesical instillation of pirarubicin hydrochloride. The observation group： using pirarubicin iaydrochloride and MMC ahernate irrigation of bladder. Results Comparison of efficacy between the observation group and the control goup, the difference was not statistically Significant （P 〉 0.05）. After treatment, the physical function and psychologial function in two aspects of the observation group less than the control group,the difference was statistically signifi- cant （P 〈 0.05）. During treatment,the total rate of advee reactions was 16.67% lower than 40% in the control group, the difference was statistically significant （P 〈 0.05）. Conclusion Prevention of glandular cystitis recurred after operion curative effect is reliable, pirarubicin hydrochloride and mitomycin ahemate bladder perfusion, the quality oq lfe of patients with higher, and adverse reaction is light, better safety.