补充大豆蛋白的减肥效果:随机对照研究的Meta分析

Effects of soy protein supplement on overweight and obese population: Meta-analysis of randomized controlled trials

目的探讨补充大豆蛋白对超重和肥胖人群肥胖指标的影响。方法检索1988年1月-2012年5月间中英文发表的随机对照研究,Meta分析计算加权均数差(WMD)及95%CI作为合并效应值,并做分层分析和灵敏度分析。结果 13篇纳入文献中,分别有12篇、7篇、7篇和11篇观察了补充大豆蛋白后体重、体质指数(BMI)、身体脂肪和腰围的效果。与对照组比较,补充大豆蛋白后体重、BMI、脂肪质量、腰围的合并效应值(95%CI)分别为-1.04kg(-1.97～-0.11)、-0.19kg/m2(-0.41～0.02)、-0.99kg(-1.73～-0.24)和-0.94cm(-1.66～-0.21)。分层分析发现欧美人群摄取大豆蛋白的减肥效果明显。结论补充大豆蛋白降低了肥胖和超重人群的体重、身体脂肪质量、腰围,具有一定的减肥效果。

Objective To study the effects of soy protein supplement on overweight and obese population. Methods Randomized controlled trials （RCT） published from January 1988 to May 2012 observing the effect of soy protein supplement on overweight and obese population were collected. Meta-analysis was applied to estimate the standardized mean difference （WMD） and 95% confidence interval （95% CI）. Results Among 13 RCTs, the number of the studies observing change of body weight, body mass index （BMI） , fat mass and waist circumference were 12,7,7 and11, respectively. Compared with the control group, the combined WMD （95% CI） of soy protein supplemented was - 1.04kg [（ - 1.97） - （ -0.11）], -0.19kg/m2[ （-0.41） - （0.02）], -0.99kg [（ - 1.73） - （ - 0.24）] and - 0.94cm [（ - 1.66） - （ -0.21 ） ] , respectively. However, the protective effect of soy protein was only observed among studies conducted in Western population, but not in Asian population. Conclusion Soy protein supplementation significantly decreased body weight, fat mass and waist circumference in overweight and obese population.