期刊文献+

不典型慢性粒细胞白血病2例并文献复习

下载PDF
导出
摘要 目的提高对不典型慢性髓系白血病(atypical chronic myeloid leukemia aCML)的认识。方法结合2例aCML患者临床资料同时分析国内外相关文献,对该类患者的临床特点、诊断及治疗进行总结。结果2例患者的临床表现无特殊,主要表现为脾大、白细胞增高、贫血、血小板、胸腔积液等相关的症状,典型特征为Ph染色体及bcr-abl融合基因阴性。具有骨髓和髓外增殖特征,伴有明显的病态造血,对治疗反应差,生存期短。结论aCML是一类临床上少见的骨髓增生异常/骨髓增殖性肿瘤,其正确的诊断依赖于骨髓形态学、分子生物学、细胞遗传学等检查。目前国内外对该病的治疗没有统一的标准,许多病例在治疗上借鉴了CML的治疗方法,生存期短、预后极差。
出处 《当代医学》 2013年第12期37-38,共2页 Contemporary Medicine
  • 相关文献

参考文献11

  • 1张志南,沈悌.血液病诊断及疗效标准[M].3版北京:科学出版社.2007:33-36.
  • 2Shepherd PC, Ganesan TS, Gaiton DA, et al , Haematological classification of the chronic myeloid leukemias[J].Bailleres Clin Haematol, 1987, 1(4),887-906.
  • 3Oscier DG.Atypical chronic myeloid leukemia,a distinct clinical entitity related to the mylelodysplastic syndrome[J]. Br J Hematol, 1996, 92(3),582-586.
  • 4Jaffe ES,Harrris NL,Stein H,et al.Pathology and genetics of tumors of haematopoietic and lymphoid tissues , World Health Organization Classfication of Tumours[M].Lyon,IARC Press,2001,47-57.
  • 5童娟,刘会兰,耿良权,孙自敏.慢性髓细胞白血病异基因外周血联合骨髓造血干细胞移植T淋巴细胞重建研究[J].白血病.淋巴瘤,2007,16(2):113-115. 被引量:3
  • 6马燕,许小平,王小钦,陈波斌,姬美容,林果为.不典型慢性髓系白血病的临床研究——附九例报告[J].中华血液学杂志,2009,30(4):279-281. 被引量:5
  • 7龚旭波,卢兴国,吴先国,肖希斌,朱蕾,张晓红,徐根波,赵小英.不典型慢性粒细胞白血病细胞形态学和组织病理学特征研究[J].中华血液学杂志,2009,30(8):563-566. 被引量:7
  • 8Hernandez JM, del ca n izo MC, Cuneo A, et al , CI inical, hematological and cytogenetic characteristics oc atypical chronic myeloid leukemia[J]. Ann Oncol,2000, 11(4),441-444.
  • 9Oinda F,Ball G,Kantarjian HM,et al.Characterstics and outcome of patients with philadelphia chromosome negative, bar jabl negative chronic myelogenous leukernia[J]. Cancer, 2002,95 (8): 1673-1684.
  • 10Koldehoff M, Beelen DW, Trenschel R, et al , Outcome of hematopietic stem cell transplantation in patients,2004,34(12). 1047-1050.

二级参考文献27

  • 1夏凌辉,方峻,游泳,郭涛,刘芳,张纯,江汇娟,邹萍.Allogeneic Peripheral Blood Hematopoietic Stem Cell Transplantation for Patients with Hematologic Malignancies[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2006,26(1):47-49. 被引量:5
  • 2周道斌,邱志峰,李太生,吕玮,赵永强,段云,江滔,沈悌.自体外周血造血干细胞移植后淋巴细胞亚群的恢复[J].基础医学与临床,2006,26(3):290-293. 被引量:4
  • 3Vardiman JW IM, Pierre R, et al. In Jaffe ES, Stein H, Vardiman JW(eds). World Health Organization Classification of Tumours: tumours of the haematopoietic and lymphoid tissues. International agency for research on cancer ( IARC ) Lyon, France. 2001 : 47- 54.
  • 4Kraemer A, Hager HD, Fruehauf S, et al. Novel constitutional translocation t ( 2 ; 12 ) ( q21 ; q22 ) is associated with kit-ligand overexpression and bcr/abl-negative chronic myelogenous leukemia. Blood, 2000, 96:352A-353A.
  • 5Score J, Curtis C, Waghorn K, et al. Identification of a novel imatinib responsive KIFSB-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia, 2006, 20:827-832.
  • 6Koch S, Jacobi A, Ryser M, et al. Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs, 2008, 188:225- 235.
  • 7Fang WB, Brantley-Sieders DM, Hwang Y, et al. Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J Biol Chem, 2008, 283:16017- 16026.
  • 8Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1 L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med, 2003, 348 : 1201-1214.
  • 9Soverini S, Martinelli G, Lacobucci I, et al. Imatinib mesylate for the treatment of chronic myeloid leukemia. Expert Rcv Anticancer Ther, 2008, 8:853-864.
  • 10Puissant A, Grosso S, Jacquel A, et al. Imatinib mesylate-resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol. FASEB J, 2008, 22: 1594-1904.

共引文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部