阿仑膦酸钠治疗绝经后骨质疏松性骨痛的研究

Treatment of bone pain due to osteoporosis with alendronate sodium in postmenopausal women

目的 观察用阿仑膦酸钠治疗 6 0例绝经后妇女的骨质疏松性骨痛的疗效。方法 对照阿仑膦酸钠使用 6个月前后疼痛 ,骨密度的变化。结果 经治疗 6个月后效果良好 ,骨痛缓解有效率达93.3% ,骨密度增加显著 ,x±s由用药前的 0 .4 6 7g/ cm2± 0 .0 36增加到用药后的 0 .52 8g/ cm2± 0 .0 37,P<0 .0 1。结论 阿仑膦酸钠通过抑制骨吸收的作用使失衡的骨代谢得以恢复 ,为治疗绝经后骨质疏松提供了一个安全可靠的治疗手段。

Objective\ We treated bone pain due to osteoporosis with alendronate sodium in sixty postmenopausal women,the period of treatment lasting six months.Methods\ comparing the changes in pain and bone mineral density (BMD) before and after 6 months of administration of alendronate. Results \ The effective rate for relief of bone pain was 93 3%.Bone mineral density increased significantly,from 0 467±0 036(g/cm 2) to 0 528±0 037(g/cm 2), P<0 01. Conclusion\ The result suggests that alendronate sodium can restore the balance of bone metabolism through inhibiting the bone resorption,and constitutes a safe and reliable treatment method for osteoporosis in postmenopausal women.