银杏内酯对NaCN及缺糖引起的PC12细胞凋亡的保护作用

Protective Effect of Ginkgolides on Apoptosis in PC12 Cells Induced by Cyanide and Glucose Deprivation

利用NaCN及缺糖引起的PC12细胞的损伤模型 ,研究了银杏内酯 (ginkgolides)对神经细胞损伤的保护作用。结果表明 ,该药物对PC12细胞损伤有显著的改善作用 ,并能显著降低凋亡细胞比率。提示银杏叶提取物 (EGb)中银杏内酯在对神经系统的保护机制中起重要作用。

NaCN and glucose deprivation treated PC12cell exhibited characteristics of apoptosis determined by electron microscopy and flow cytometry Ginkgolides(10mg/L)was shown to inhibit apoptosis and protect PC12 cells against injury, suggesting that ginkgolides play an important role in neuroprotective activities of ginkgo biloba extracts