半夏泻心汤加减对非糜烂性反流病症状和生活质量的影响

Influences of modified Banxia Xiexin Tang on symptoms and quality of life in patients with non-erosive reflux disease

目的评价半夏泻心汤加减治疗非糜烂性反流病寒热错杂证的疗效和对患者生活质量的影响。方法将127例非糜烂性反流病寒热错杂证的患者随机分为2组,治疗组64例,对照组63例,治疗组给予半夏泻心汤加减治疗,每日2次,对照组给予泮托拉唑治疗,每次40 mg,每日1次。连续用药8周,分别于治疗前及治疗后采用反流性疾病诊断问卷(RDQ),匹兹堡睡眠质量指数(PSQI),医院焦虑抑郁量表(HAD)评价临床疗效和生活质量。结果治疗组总有效率为87.50%,与对照组比较,无统计学意义(P>0.05)。治疗组治疗后的RDQ总积分,烧心、反酸、胸骨后疼痛的RDQ症状频度积分,烧心、反酸、胸骨后疼痛、反食的RDQ症状程度积分均较治疗前有统计学意义(P<0.05、P<0.01),与对照组比较无统计学意义(P>0.05)。治疗组治疗后的PSQI、HAD积分与对照组相比,具有统计学意义(P<0.05)。结论半夏泻心汤加减能有效改善非糜烂性反流病寒热错杂证患者反流症状,疗效与泮托拉唑相似,同时能提高睡眠质量,缓解焦虑抑郁情绪,提高生活质量,优于单用泮托拉唑。

Objective To review the curative effect of modified Banxia Xiexin Tang on cold-heat complex syndrome of non-erosive reflux disease （NERD） and its influence on the quality of life. Methods The patients （ n = 127 ） were randomly divided into treatment group （ n = 64 ） and control group （ n = 63 ）. The treatment group was treated with modified Banxia Xiexin Tang twice a day for 8 weeks, and control group, with pantoprazole （40 mg） once a day for 8 weeks. The curative effect and quality of life were reviewed by applying Reflux Disease Diagnostic Questionnaire （ RDQ ）, Pittsburgh sleep quality index （PSQI） and Hospital Anxiety and Depression Scale （HAD） before and after treatment. Results The total effective rate was 87.50% in treatment group but it was not statistically significant compared with control group （P 〉 0.05）. In treatment group, the total integral of RDQ, RDQ frequency integrals of heartburn, acid reflux and retrostemal pain, and RDQ degree integrals of heartburn, acid reflux, retrosternal pain and regurgitation were statistically significant after treatment compared with those before treatment （P 〈 0.05, P 〈 0.01 ）, but were not statistically （P 〉 0.05 ）. The integrals of PSQI and HAD were statistically significant compared with control group significant in treatment group compared with control group （P 〈 0. 05 ） after treatment. Conclusion Modified Banxia Xiexin Tang can effectively relieve the reflux symptoms and its curative effect is similar to that of pantoprazole in the patients with cold-heat complex syndrome of NERD. At the same time, it can improve the quality of sleep and quality of life and is better than pantoprazole.