畜产动物过氧化物酶体增殖物激活受体基因的表达模式及功能研究进展

Research Advances in Expression Patterns and Functions of Peroxisome Proliferator-Activated Receptors Genes in Livestock Animals

过氧化物酶体增殖物激活受体(PPARs)是一类配体依赖的核转录因子,属核受体超家族成员。自从PPARs于1990年被发现以来,研究人员对啮齿动物和人体PPARs基因的结构与多态性、组织中表达模式、影响表达的因素、信号传导途径以及调控脂类代谢等方面的功能进行了广泛和深入的研究。近年来,PPARs基因在畜禽及鱼类中的表达模式及功能的研究也逐渐开展起来,并取得了一些进展。本文对PPARs基因在畜产动物组织中的表达模式及功能研究进行了综述。

Peroxisome proliferator-activated receptors （ PPARs）, the ligand-depended nuclear transcription fac- tors, are members of the nuclear receptor superfamily. Since PPARs had been founded in 1990, the PPARs genes＇ structure and polyrnorphism, expression patterns in tissues, influence factors of expression, signal transduction pathway and functions like regulating lipid metabolism in the rodent and human body were studied widely and deeply by researchers. In recent years, the expression patterns and functions of PPARs genes in livestock, poultry and fish have been also researched gradually. This article reviews expression patterns and functions of PPARs genes in the livestock animals.