猴实验性肺螨感染的病理学观察

Pathological Observation of Lung Mites Infection in Monkey

目的探讨尘螨实验性感染猴肺的结局,观察能否产生猴肺部感染性病理改变.方法实验猴经气管注入含活螨蒸馏水混悬液,复制猴肺螨病模型.常规石蜡切片HE染色.结果接种螨虫第12天起,实验猴肺组织出现色灰白或略带黄色囊状病灶,囊内经解剖镜观察及病理学证实有螨虫,为螨虫性肺病变.结论尘螨经气管实验性感染猴肺可导致猴肺感染性病灶发生,猴肺螨感染性病理改变主要表现为囊肿样增生性病灶.

Objective To explore the final result of lung mites experimental infection in monkey,and observe the monkey lung infectious pathological changes produced whether or not.Methods The monkeys were poured into suspension liquid with mites by trachea,and the lung mite infection model was reproduced.Routine sections were stained with HE.Results After monkeys lung was poured into suspension liquid with mites 12 days,the lung tissues of monkeys appeared grey with yellow color cystic lesions,and the mites was found by anatomical microscope in cystic lesions.Conclusions Mites experimental infection the monkey lung by the tracheal could lead to the occurrence of infectious lung lesions.The cystic hyperplastic lesion was the main performance feature of monkey lung mites infectious pathological changes.