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JAK/STAT信号转导通路在肝纤维化形成中的作用 被引量:14

Current perspectives on the JAK/STAT signaling pathway and its activating factors in liver fibrosis
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摘要 JAK/STAT信号转导通路是一条由多种细胞因子和生长因子介导的信号转导通路,能参与细胞的增殖、分化、凋亡及炎症等病理生理过程。研究表明,JAK/STAT通路在肝纤维化的形成进程中具有重要的调控作用。本文就近年JAK/STAT信号转导通路在肝纤维化形成过程中的作用作一综述。 The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling pathway is an important signal transduction pathway activated by a variety of cytokines and growth factors and mediates various cellular processes involved in liver fibrosis,including proliferation,differentiation,apoptosis,and inflammation.In this article,the recent findings related to the function of JAK/STAT signaling and its activating factors in liver fibrosis are reviewed.Specifically,the roles of three cytokines leptin,interferon-alpha(IFN-α) and interleukin-4(IL-4) are detailed in regards to their activation of the intracellular JAK/STAT pathway through the hepatic stellate cell membrane to promote expression of target genes involved in the fibrotic process.
作者 潘金 琚坚
出处 《临床肝胆病杂志》 CAS 2013年第5期393-396,共4页 Journal of Clinical Hepatology
关键词 Janus激酶类 STAT转录因子类 信号传导 肝硬化 Janus kinases STAT transcription factors signal transduction liver cirrhosis
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