期刊文献+

抗孕唑对妊娠大鼠子宫蜕膜、前列腺素含量和宫缩的影响 被引量:2

EFFECTS OF DL111-IT ON DECIDUA, PGs CONTENTS AND UTERINE CONTRACTILITY IN PREGNANT RATS
下载PDF
导出
摘要 目的 研究抗孕唑对妊娠大鼠子宫蜕膜组织形态 ,PGF2α和PGE2 含量及对离体大鼠子宫收缩幅度的影响。方法 用HE染色 ,放射免疫法和离体子宫收缩记录等方法。结果 抗孕唑使妊娠大鼠子宫蜕膜细胞受损、剥离 ,并使子宫和血清中PGE2 和PGF2α的含量升高 ;对离体妊娠大鼠子宫有收缩作用 ,其效价为米索前列醇的 0 6倍。结论 抗孕唑损伤蜕膜细胞 ,刺激释放前列腺素 。 AIM To observe the effects of DL111 IT on decidual cells, content of PGE 2 and PGF 2α , and uterine contractibility of pregnant rats. METHODS HE stain, radioimmunoassay and uterine contractility in vitro were used to estimate histologitic changes in decidual cells, PGE 2 and PGF 2α concentration in uterus and serum and the uterine contrability of pregnant rats, respectively. RESULTS After im DL111 IT ×5 d, the PGE 2 and PGF 2α contents in uterus of pregnant rats increased 118 2% and 213 7%, respectively, and those in serum were increased 74 3% and 227 7%, respectively. Edema, degeneration and solvate at decidual cells with indefinite nuclei were observed in pregnant rats treated with DL111 IT for 3~5 days. DL111 IT strengthened the uterine contraction of pregnant rats and the uterine response to oxytocin and misoprostol in vitro . CONCLUSION DL111 IT damaged the decidual cells, incresed the concentrations of PGE 2 and PGF 2α , and strengthened the contractibility of pregnant uterine.
出处 《药学学报》 CAS CSCD 北大核心 2000年第9期641-644,共4页 Acta Pharmaceutica Sinica
基金 上海市自然科学基金!(97ZD14 0 2 7)
关键词 抗孕唑 前列腺素 子宫蜕膜 子宫收缩 人工流产 DL111 IT prostaglandins uterine contractibility
  • 引文网络
  • 相关文献

参考文献2

  • 1Yang B,Eur J Pharmacol,1999年,380卷,145页
  • 2Yang B,药学学报,1996年,17卷,4期,361页

同被引文献7

引证文献2

;
使用帮助 返回顶部