期刊文献+

白桦三萜类物质的抗肿瘤作用及其对免疫功能的增强效应 被引量:52

Antitumor activity and immunoregulatory effect of triterpenes isolated from betula platyphylla
下载PDF
导出
摘要 目的 :研究白桦三萜类物质 (TBP )体内抗肿瘤作用及其对荷瘤小鼠免疫功能的影响。方法 :利用小鼠体内移植瘤模型 ,测定TBP对小鼠黑色素瘤B16、肉瘤S180、Lewis肺癌和艾氏腹水癌等肿瘤的抑瘤率。采用放射性掺入法检测ConA诱导的脾细胞增殖反应 ;放射性释放法检测巨噬细胞细胞毒活性 ;中性红释放法检测TNF和NK细胞活性。结果 :TBP对各瘤株的抑瘤率均达到 30 %以上 ,对黑色素瘤B16的效果最好 ,抑瘤率为 5 1 4%。TBP对ConA诱导的增殖反应和NK细胞活性无明显影响 ,但可促进巨噬细胞和脾细胞分泌TNF ,增加巨噬细胞的细胞毒活性。结论 :TBP具有良好的抗肿瘤作用 。 Objective:To study the antitumor activity and immunoregulatory effect of Triterpenes isolated from Betula Platyphylla (TBP) Methods: Inhibition rate (IR) on tumor growth was determined by the mice with transplantable tumors (melanoma B16, Sarcoma 180, Lewis lung carcinoma and Ehrlich ascites cancer ) , splenocyte proliferation induced by ConA was measured by 3H TdR incorporation ; cytotoxicity of macrophage was observed by 3 H TdR release; activity of TNF and NK cell was determined by dye (natural red)release Results: IR of 0 80 g/kg and 1 20 g/kg TBP on all of above tumor strains were greater than 30% in vivo TBP does not show significant effect of splenocyte proliferation and NK cell activity, but significantly promoted the activity of TNF producted by macroghage and splenocyte TBP also increase the cytotoxicity of macrophage Conclusion:TBP shows potent antitumor effect in vivo Promoting nonspecific immunoactivity is one of the antitumor mechanism of TBP
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2000年第9期485-487,共3页 Chinese Journal of Immunology
基金 吉林省科委资助!(NO 970 5 5 9 4)
关键词 白桦三萜类物质 抑瘤率 免疫功能 中药 Triterpenes isolated from betula platyphylla (TBP) Tumor inhibition rate Immunoregulatory
  • 引文网络
  • 相关文献

参考文献6

  • 1李时珍.本草纲目[M].人民工艺出版社,1978..
  • 2江苏新乡医学院.中药大辞典[M].上海:上海科学技术出版社,1986.333-333.
  • 3韩悦.抗癌药物研究与实验技术[M].北京:北京医科大学和中国协和医科大学联合出版社,1997.295-295.
  • 4韩悦,抗癌药物研究与实验技术,1997年,295页
  • 5江苏新乡医学院编,中药大辞典,1986年,333页
  • 6李时珍,本草纲目,1978年,2047页

共引文献7

同被引文献589

引证文献52

二级引证文献484

;
使用帮助 返回顶部