布拉氏酵母菌预防婴儿抗生素相关性腹泻临床分析

Clinical analysis of Boulardii to prevent anti-biotic-associated diarrhea in pneumonia infant

目的 :探讨布拉氏酵母菌对婴儿期肺炎患儿抗生素相关性腹泻的预防作用。方法:237例静脉应用抗生素的肺炎住院婴儿完全随机分为两组,预防组120例治疗开始即同时服用布拉氏酵母散;对照组117例,在出现腹泻后加用布拉氏酵母菌散;出现腹泻后两组均同时使用思密达散及适当补液。比较两组腹泻的发生率、疗效、腹泻持续时间并进行统计分析。结果:预防组出现腹泻21例,发病率为17.50%;对照组出现腹泻43例,发病率为36.75%。预防组患儿腹泻持续时间(3.14±1.24)d,较对照组时间(4.28±1.53)d短,差异有统计学意义(P<0.01)。预防组腹泻患儿总有效率为95.24%,较对照组69.77%高,差异有统计学意义(P=0.046)。结论:布拉氏酵母菌能有效预防婴儿肺炎患儿抗生素相关性腹泻的发生,并可缩短腹泻持续时间。

Objective： To explore the prevention of antibiotic-associated diarrhea by Boulardii in pneumonia infant. Methods： In a prospective randomized trial, 237 infant were enrolled, and divided into 2 groups. Boulardii was administered to 120 infant who received antibiotic therapy before diarrhea （prevention）; The other 117 infant after diarrhea were control. The incidence of antibiotic-associated diarrhea was compared in two groups. Results： The incidence of diarrhea was 17.50% in prevention group and 36.75% in control, group. The mean duration of diarrhea was （3.14 ±1.24） d in prevention group and （4.28 ± 1.53） d in control group. There was significant difference between two groups （P〈0.01）. The overall response rate was 95.24% in prevention group and 69.77% in control group, respectively. Conclusion： The use of Boulardii can prevent antibiotic-associated diarrhea in infant and can shorten the duration of diarrhea.