转化生长因子β1对软骨组织代谢影响的研究进展

Transforming growth factor beta 1 effects on cartilage tissue metabolism

背景:转化生长因子β1可以介导软骨合成、抑制胶原和蛋白多糖分解,在诱导软骨分化和维持软骨表型上起着重要作用,实现软骨缺损的功能性修复。目的:从生物学特性、在生物工程中的应用、基因多态性、信号通路及微小RNA等方面综述转化生长因子β1对软骨组织代谢影响的研究进展。方法:以"transforming growth factor-β1,Cartilage Differentiation,cartilage matrix"为英文检索词,以"转化生长因子β1,软骨分化,软骨基质"为中文检索词。经第一作者检索2007/2012CNKI数据库及SPRINGERLINK数据库有关转化生长因子β1对软骨组织代谢影响的研究进展方面的文献130篇,根据纳入排除标准保留54篇进行总结。结果与结论:转化生长因子β1可诱导间充质细胞向软骨细胞分化,促进软骨特异性基质的合成,保护软骨基质不被各种蛋白酶水解破坏,能够增强软骨组织自身再生能力,实现使软骨的损伤逆转,在软骨修复领域展现了巨大的潜在应用价值。

BACKGROUND： Transforming growth factor beta 1 can mediate cartilage synthesis and inhibit decomposition of collagen and protein polysaccharide, which has a most important effect on induction ofcartilage differentiation in vitro and maintenance of cartilage phenotype, realizing the functional repair of cartilage defects. OBJECTIVE： Based on the biological characteristics, applications in biotechnology, gene polymorphism, signaling pathways and microRNA, to introduce research progress of transforming growth factor beta 1 influence on cartilage tissue metabolism. METHODS： The first author searched CNKI and SPRINGERLINK databases （2007/2012） to retrieve articles related to transforming growth factor beta 1 influence on cartilage tissue metabolism using the key words of ＂transforming growth factor beta 1, cartilage differentiation, cartilage matrix＂ in Chinese and English, respectively A total of 130 articles were retrieved, and finally 54 were included. RESULTS AND CONCLUSION： Transforming growth factor beta 1 can induce chondrogenic differentiation of mesenchymal stem cells, promote cartilage-specific matrix synthesis, protect the cartilage matrix against proteolysis, enhance self-renew ability of cartilage tissues, and realize repair of cartilage injury. In the field of cartilage repair, transforming growth factor beta 1 demonstrates a great potential value.