期刊文献+

低分子肝素在子痫前期和复发性流产中的应用进展 被引量:22

下载PDF
导出
摘要 妊娠妇女处于生理性血液高凝状态,如果凝血、抗凝及纤溶系统功能紊乱,则出现血栓前状态(prethromboticstate.PTS),若胎盘形成血栓,发生局部梗死,可严重影响孕产妇及围生儿预后。产科疾病中子痫前期(preeclampsia,PE)、复发性流产(recurrentspontaneousabortion,RSA)、胎儿生长受限及胎盘早剥等,均与PTS、胎盘缺血梗死和胎盘微血栓形成有关。因此,抑制胎盘微血栓形成或许能具有一定的预防及治疗效果,但临床应用抗血栓药物仍有很大争议性。
出处 《实用医学杂志》 CAS 北大核心 2013年第12期1894-1896,共3页 The Journal of Practical Medicine
基金 广东省科技计划项目(编号:2007B030502015)
  • 相关文献

参考文献26

  • 1Greer I A. Thrombosis in pregnancy: maternal and fetal issues[J]. Lancet, 1999,353(9160): 1258-1265.
  • 2Y urdakok M. Fetal and neonatal effects of anticoagulants used in pregnancy: a review[J]. TurkJ Pediatr, 2012,54 (3): 207-215.
  • 3邓娅莉,丁依玲.早发型子痫前期4种治疗方案的临床疗效研究[J].实用妇产科杂志,2011,27(9):690-693. 被引量:41
  • 4D'Ippolito S, Ortiz A S, Veglia M, et al. Low molecular weight heparin in obstetric care: a review of the literature[J]. Reprod Sci, 2011,18(7) :602-613.
  • 5GrisJ C, Chauleur C, FaillieJ L, et al. Enoxaparin for the secondary prevention of placental vascular complications in women with abruption placentae[J]. Thromb Haemost, 2010, 104 ( 4): 771-779.
  • 6Martinelli I, Ruggenenti P, Cetin 1, et al. Heparin in pregnant women with previous placenta-mediated pregnancy complica-tions: a prospective, randomized, multicenter, controlled clinical trial[J]. Blood, 2012,119(14):3269-3275.
  • 7林建华,张建平,贺晶,黄引平,余艳红.低分子肝素在产科中的应用[J].现代妇产科进展,2007,16(6):401-409. 被引量:64
  • 8CheckJ H. The use of heparin for preventing miscarriage[J] . AmJ Reprod Immunol, 2012,67(4):326-333.
  • 9Franklin R D, Kutteh W H. Effects of unfractionated and low molecular weight heparin in anti phospholipid antibody binding in vitro[J]. Obstet Gynecol, 2003, 101 (3) : 455-462.
  • 10Mulla MJ, BrosensJ J, Charnley L W, et aI. Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4 MyD88 pathway[J]. AmJ Reprod Immunol, 2009, 62 ( 2 ) : 96-111.

二级参考文献8

共引文献103

同被引文献158

  • 1刘玉昆,王蕴慧,刘颖琳,张睿,张建平.低分子肝素治疗不明原因复发性自然流产57例分析[J].中华临床医师杂志(电子版),2011,5(16):4916-4918. 被引量:32
  • 2胡乔飞,李坚.遗传性血栓形成倾向与反复自然流产的研究进展[J].生殖与避孕,2006,26(10):610-617. 被引量:17
  • 3刘宗花,王谢桐.低分子肝素治疗自身免疫型复发性流产的作用机制及安全性[J].山东医药,2007,47(20):114-115. 被引量:42
  • 4谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,2013:258-264.
  • 5Mantha S, Bauer KA, Zwicker JI. Low molecular weight heparinto achieve live birth following unexplained pregnancy loss : asystematic review [J]. J Thromb Haemost, 2010,8(2) :263-268.
  • 6Mulla MJ, Brosens JJ, Cha mLey LW, et al. Antiphospholipidantibodies induce a pro-inflamatory response in first trimestertrophoblast via the TLR4 MyD88 pathway [J]. Am J ReprodImmunol, 2009,62(2):96-111.
  • 7黄灿丽.低分子肝素钙治疗复发性流产的研究[J].医药前沿,2013,3(11):28-29.
  • 8江明性,杨藻宸.药理学[M].4版.北京:人民卫生出版社,2013:208-209.
  • 9FIGUEIR6-FILHO EA, DE OLIVEIRA VM, BREDA I, et al. Usefulness of a scoring system on perinatal outcomes in pregnant women with thrombophilia in the effectiveness of an enoxaparin- based intervention [J]. Rev Bras Ginecol Obstet, 2012,34 (10) :459-465.
  • 10GALAMBOSI PJ,KAAJA RJ,STEFANOVIC V. Safety of low molecular weight heparin during pregnancy:a retrospective controlled cohort study [J]. Eur J Obstet Gynecol Reprod Biol, 2012. 163(2) : 154-159.

引证文献22

二级引证文献293

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部