摘要
建立了采用高效液相色谱·质潜联用法（Lc-MS．Ms）测定玩具材料中总量双酚A的检测方法。样品经二氯甲烷萃取，通过旋转蒸发仪进行净化后，采用C18柱，以甲醇-水混合液为流动相，等比例洗脱分离，经串联四级杆质谱仪在负离子模式下以多反应监测模式进行检测。结果表明：该方法在0．01-10mg／L范围内线性关系良好，线性方程的相关系数r2=0．9993。该方法的检出限为0．005mg／kg；在20ml啦g、50mg／kg和80mg／kg三个添加浓度水平下t玩具材料中双酚A的平均回收率为76．8％～99．0％。相对标准偏差（n=：6）均小于10．0％。该方法操作简便，灵敏度高，适用于玩具原材料、玩具及儿童产品部件中双酚A的总含量测定。
A comprehensive analytical method based on high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） has been developed for bisphenol A from toys material. The sample was extracted with dichloromethane. Sample concentration and purification was performed on rotary evaporator. And then, the separation compound was analyzed with a ZORBAX Eclipse Plus C18 column by isocratic elution with methyl alcohol- H20 as mobile phase. After gradient elution separation, the analyte was detected under multiple reaction monitoring （MRM） with electrospry ionization in negative ion mode （ESI-）. The calibration curves for bisphenol A was linear in the range of 0.01-10 mg/L and the correlation coefficient were 0.9993. The quantitation limit was 0.005 mg/kg. The mean recoveries at three spiked concentration levels of 20 mg/kg, 50 mg/kg, 80 mg/kg were in the range of 76.8 %-99.0 % with RSDs（n=6） less than 10 %. This method is simple, accurate and rapid, and is suitable for the inspection of bisphenol A from toy materials.
出处
《广东化工》
CAS
2013年第12期172-173,共2页
Guangdong Chemical Industry
