乳腺癌及其癌前病变中p53,bcl-2,c-myc蛋白的表达

Expression of p53, bcl-2, c-myc proteins in breast cancer and its precancerous lesion

[ 目的 ]通过检测乳腺癌及其癌前病变中 p5 3,bcl 2 ,c myc蛋白的表达 ,探讨其在乳腺组织恶性转化进程中的作用 .[方法 ]应用免疫组织化学方法原位观察了 31例乳腺癌 ,2 0例乳腺不典型增生 ,2 0例乳腺单纯性增生中p5 3 ,bcl 2 ,c myc蛋白的表达 ,以 8例正常组织作对照 .[结果 ]p5 3,c myc蛋白在乳腺癌中阳性率分别为 6 7% ,6 4% ,均高于正常组织 ;在乳腺不典型增生中阳性率分别为 5 0 % ,5 0 % ,也高于正常组织 ;在乳腺单纯性增生中阳性率分别为 40 % ,30 % .bcl 2蛋白在乳腺癌、乳腺不典型增生及单纯性增生中阳性率分别为 77% ,85 % ,90 % .[结论 ]p5 3 ,c myc蛋白的过表达、bcl

OBJECTIVE To investigate the effects of p53, bcl 2, c myc proteins in different stages of malignant transformation of breast cancer and its precancerous lesions. METHODS The expression of p53, bcl 2, c myc proteins was detected in 31 cases of breast cancer,20 dysplasia and hyperplasia in situ by using immunohistochemical staining. RESULTS The positive rate of p53 and c myc proteins was 67%, 64% respectively in breast cancer, 50%, 50% in dysplasia and was higher than that in normal, and 40%, 30% in hyperplasias. The positive rate of bcl 2 in breast cancer, dysplasia and hyperplasia were 77%, 85% and 90%, respectively. CONCLUSION The excessive expression of p53, c myc proteins and descended expression of bcl 2 protein play an important role in the malignant transformation of breast tissue.