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栀子兰色素可能为栀子粉末外用抗炎消肿时的活性物质 被引量:14

GARDENIA BLUE PIGMENTS MAY BE ESSENTIAL TO ANTI INFLAMMATORY ROLE OF THE FRUITS OF GARDENIA JASMONOIDES ELLIS
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摘要 传统中药山栀子中的环烯醚萜成分及尼平 ( genipin)与甘氨酸反应可形成兰色色素 ,初步药理实验显示 ,该兰色色素对小鼠具有抗炎和镇痛作用。推测栀子兰色素可能为民间将栀子粉末外用抗炎消肿时的活性物质。 To study relationship between Gardenia blue pigment and amti inflammatory effect of fruits of Gardenia jasminoides .Methods:Blue pigments were derived from glycine and iridoid compounds genipin and mussaenoside.Anti inflammatory and analgesic effects of the blue pigments were evaluated in mice at dosages of 25 mg/kg and 30 mg/kg,respectively.Results:Blue pigment 1 exhibited anti inflammatory and analgesic effects,blue pigment 2 exhibited anti inflammatory effect,and the effect was much stronger than that of mussaenoside.Conclusion:These blue pigments may contribute to the therapeutic role of fruits of Gardenia jasminoides when the powder of which were used externally to subside swelling in folk medicine.
出处 《天然产物研究与开发》 CAS CSCD 2000年第4期41-44,共4页 Natural Product Research and Development
关键词 山栀子 天然兰色素 中药 药理 抗炎活性 Gardenia jasminoides ,iridoid,natural blue pigment,anti inflammatory activity,analgesic activity,swelling subsiding
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参考文献3

  • 1Zhao W M,Natural Product Sciences,1995年,1卷,1期,61页
  • 2韩公羽,植物药活性成分的研究与开发,1991年,109页
  • 3江苏新医学院,中药大辞典,1986年

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