CD68在胃癌组织中表达的意义及对肿瘤复发的影响

Significance of CD68 expression in gastric cancer tissues and tumor recurrence

目的探讨巨噬细胞在不同分期的胃癌组织中的浸润情况以及对胃癌术后复发率的影响。方法采用免疫组化染色法检测CD68在52例胃癌术后病人组织中的表达,比较不同分期的胃癌组织中CD68表达的差异,以及CD68对胃癌术后病人复发率的影响。结果 52例胃癌组织切片中均见CD68表达,巨噬细胞浸润的密度为23-154/HP;肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)在Ⅰ-Ⅱ期胃癌组织浸润的密度为41.02±8.47/HP,在Ⅲ期浸润的密度为74.10±13.49/HP,在Ⅳ期浸润的密度为126.10±13.35/HP,三者比较有明显差异(P<0.05)。高密度TAM浸润病人术后1年、2年、3年的累计复发率明显高于低密度的病人(P<0.05)。结论巨噬细胞在胃癌组织中的浸润随着胃癌分期增加而增加,高密度浸润的肿瘤相关巨噬细胞预后差且更容易出现术后的复发。

Objective To explore macrophage infiltration in different stages of gastric cancer tissue and its effect on gastric cancer recurrence rate.Methods Using immunohistochemical staining to detect CD68 in 52 cases of postoperative patients with gastric cancer tissues,and comparison of different stages of the differential expression of CD68 in gastric cancer tissues,and CD68 in patients with gastric cancer recurrence after effect.Results In 52 cases of gastric cancer tissue sections were seen in CD68 expression of macrophage infiltration,density is 23-154/HP.TAM in stage Ⅰ-Ⅱ infiltration density was 41.02±8.47/HP,in stage Ⅲ infiltration density was 74.10±13.49/HP,and in stage Ⅳ infiltration density was 126.10±13.35/HP.There is obvious difference between the three（P0.05）.High density TAM infiltration cumulative recurrence patients after 1 years,2 years,3 years was significantly higher than that of the low density of the patients（P0.05）.Conclusion Macrophage infiltration in gastric cancer tissues increases with the increase in gastric cancer staging,and the high density of tumor-associated macrophage infiltration and more prone to postoperative recurrence and poor prognosis.