2型糖尿病患者抗凝血酶Ⅲ、凝血酶时间的检测分析

Study on Detection of Anti-thrombin Ⅲ and Thrombin Time in the Datiests with Type 2 Diabetes

目的探讨凝血指标中AT-Ⅲ、TT变化在糖尿病及其并发症中的临床意义。方法用Sysmex CA7000全自动凝血分析仪检测2型糖尿病患者和正常人血浆中抗凝血酶III(AT-III)、凝血酶时间(TT)。结果 2型糖尿病患者体内存在着高凝倾向,其血浆中AT-Ⅲ低于健康对照组(P<0.05),而TT指标明显比健康对照组延长(P<0.01)。结论检测糖尿病患者AT-Ⅲ、TT,可了解糖尿病微血管病变与凝血活化状态与血栓形成状况之间的关系,为糖尿病的疗效和预后提供依据。

eetive To detect the clinical values of anti-thrombin II（AT-III） and thrombin time （TT） in patients with type 2 diabete but also in complications. Methods CA7000 was used for detection of type 2 diabetic patients and control group＇s anti-thrombin III（AT-III） and thrombin time （TT）. Results The patients with type 2 diabete were in hypercoagulable state easily .The AT-III in group of type 2 diabetes were significantly lower than that of the normal control one, and TT is significantly longer than the normal control one. Conclusion The detection of AT-III and TT could help clinical doctors to observe the correlation between microangiopathy disease and thrombin activation, which is useful for diagnosis and avoiding the vascular pathological changes.