早孕期颈部透明层检测在产前诊断中的作用

Role of Nuchal Translucency Detection in Prenatal Diagnosis during Early Pregnancy

目的探讨超声早孕期颈部透明层(NT)检测的方法及在产前诊断中的意义。方法对2 820例行产前检查的孕妇,均采用超声测量胎儿NT值并进行染色体核型检查。结果 2 820例孕妇中胎儿NT>3.0 mm者34例,筛查阳性率为1.21%;NT平均厚度为(7.29±1.52)mm。34例行染色体检查,染色体正常者9例,其中4例伴有水囊瘤,2例伴有全身水肿;染色体异常者25例,其中9例为Turner综合征,8例为21-三体综合征,5例为18-三体综合征,3例为染色体平衡易位。结论 NT测量对于孕妇产前诊断染色体异常及胎儿结构异常具有重要的临床意义。

significance in Objective To investigate the method for nuchal translucency （NT） detection and its prenatal diagnosis during early pregnancy. Methods A total of 2 820 pregnant women who were chose to undergo prenatal examination received ultrasound measurement of fetal NT and chromosome detection. Results Among the 2 820 pregnant women, 34 （1.21%） had a fetal NT greater than 3.0 mm. The average NT thickness was （7.29＋1.52） mm. Among the 9 pregnant women with normal chromosome, 4 had cystic hygroma and 2 had anasarca. Among the 25 pregnant women with abnormal chromosome, 9 had Turner syndrome, 8 had 21 trisomy syndrome, 5 had 18 trisomy syndrome, and 3 had balanced translocation of role in the diagnosis of chromosomal chromosome. Conclusion The NT and structural abnormalities during measurement plays an important early pregnancy.