肺结核患者耐多药监测结果分析

Analysis of monitoring results of multi-drug resistant pulmonary tuberculosis patients

目的了解结核分枝杆菌耐药状况。方法在监测县收集结核菌株,用比例法进行4种抗结核药物异烟肼(INH)、链霉素(SM)、乙胺丁醇(EMB)、利福平(RFP)的药物敏感性测定。结果监测质量控制指标完成较好,388株结核分枝杆菌总耐药率为14.7%,耐多药率为4.6%。初始耐药率和获得性耐药率比较差异无统计学意义(P>0.05),初始耐多药率和获得性耐多药率比较差异有统计学意义(P<0.05)。4种抗结核药物的耐药率由高到低分别为INH(9.5%)、SM(7.7%)、RFP(6.7%)、EMB(2.3%)。不同性别组间的耐药率差异有统计学意义(P<0.05)。结论当前结核病控制工作取得一定成效,应继续贯彻以控制结核病传染源为重点,加强质量管理的措施,阻止耐药结核病的流行,定期监测,掌握耐药流行趋势,为评价和制订结核病控制措施提供科学依据。

Objective To understand the status of drug resistance of Mycobacterium tuberculosis. Methods Collection of Mycobacterium tuberculosis in monitoring the county, with the proportion of 4 kinds of anti-tuberculosis drug isoniazid （INH）, streptomycin （SM）, ethambutol （EMB）, rifampicin （RFP） determination of the drug sensitivi- ty. Results Monitoring quality control indexes completed we11,388 strains of Mycobacterium tuberculosis total drug resistance rate was 14. 70//00 ,multiple drug resistance rate was 4.6%. The initial drug resistance and acquired resist- ance had no significant difference（P^0.05） ,there was significant difference in multi-drug resistant rate （P^0.05）. Four kinds of anti-tuberculosis drug resistance rate from high to low were respectively IN H （9.5 ~）, SM （7.7 ~ ）, RFP （6.7 % ）, EMB （2.3 % ）. Drug resistance of different gender groups had significant difference（P^0.05）. Con- clusion The current tuberculosis control work has achieved certain results, should continue to carry out to control tuberculosis infection source as the focus, strengthen quality management, prevent drug-resistant tuberculosis epidem- ic, regular monitoring of drug resistance,grasp the popular trend,to provide a scientific basis for evaluating and devel- oping tuberculosis control measures.