帕瑞昔布钠对腹腔镜胆囊切除麻醉苏醒期躁动及术后疼痛的影响

Effects of parecoxib sodium on agitation after general anesthesia and postoperative pain of the patients undergoing laparoscopic cholecystectomy

目的观察帕瑞昔布钠不同时点给药对于腹腔镜胆囊切除手术患者苏醒期躁动及术后疼痛的影响。方法将ASAⅠ～Ⅱ级行腹腔镜胆囊切除的患者60例,随机分为三组,每组20例。A组麻醉前5分钟注射帕瑞昔布钠40mg,B组手术结束前5分钟静注帕瑞昔布钠40 mg,C组为对照组静注生理盐水;三组术后均不行PCIA。观察苏醒期躁动(RS)评分并分别于术后2、6、12、24 h记录VAS镇痛评分。结果与C组比较,A、B两组RS评分均明显降低(P<0.05),而A、B两组之间RS评分比较差异则无统计学意义;A、B两组各时点VAS评分相比较于C组也显著降低(P<0.05),与B组比较A组6、12 h的VAS评分显著降低(P<0.05)。结论帕瑞昔布钠可明显减轻全麻术后疼痛,降低苏醒期躁动的发生率,而超前使用术后镇痛效果更加显著。

：Objective To investigate the effects of parecoxib sodium on agitation after general anesthesia and postoperative pain of the patients undergoing laparoscopic cholecystectomy. Methods Sixty ASA I or ]I patients scheduled for laparoscopic cholecystectomy were randomly assigned into 3 groups （n = 20 each） ：Patients in groups A （5 min before anesthesia）and B （5 min before operation ）were infused parecoxib sodium at a dose of 40 rag;patients in group C were infused 0.9% NS. The VAS were recorded postoperatively at hours 2,6,12 and 24, and the RS as well. Results Compared with group C, the RS scales were decreased in group A and B （ P 〈 0.05）. The VAS scales were decreased at the four time points in group A and B compared with group C （ P 〈 0.05 ）. Compared with group B, the VAS scale at 6,12 were decreased in group A （P 〈 0.05 ）. Conclusion Parecoxib sodium infusing can obviously reduce agitation after gener- al anesthesia and relieve postoperative pain. Preemptive analgesia with parecoxib sodium was better than the usual.