在中华骨髓库找到HLA匹配无关供者的概率

Probability of finding HLA-matched unrelated marrow donor from Chinese Marrow Donor Program

目的计算在中华骨髓库(CMDP)找到HLA匹配无关供者的概率,探讨骨髓库最佳库容量。方法根据HLA表型频率计算找到HLA匹配供者概率。结果在中华骨髓库248 978名HLA等位基因分型供者中,找到至少1例HLA-A,-B,-DRB1等位基因6/6匹配、HLA-A,-B,-C,-DRB1等位基因8/8匹配、HLA-A,-B,-C,-DRB1,-DQB1等位基因10/10匹配供者的概率,分别为0.358 1、0.274 9、和0.234 7。根据籍贯将供者分为北方和南方2大群体,在114 767名北方供者群体和114 767名南方供者群体中,找到至少1例6/6、8/8、10/10匹配供者的概率分别为0.240 5和0.338 3,0.180 7和0.262 8,0.155 0和0.222 5。结论 CMDP供者南北群体之间存在遗传学差异,北方供者HLA多态性高于南方供者。选择性增加特定籍贯供者,可提高该籍贯患者找到HLA匹配供者的概率。

Objective To estimate the probability of finding HLA matched unrelated marrow donor in registry of Chinese Marrow Donor Program （CMDP）. Discuss the optimal size of bone marrow donor registry in China Methods The probability of finding at least one HLA matched unrelated donor was calculated based on the HLA phenotype frequency. Results The probability of finding HLA-A,-B,-DRB1 allele 6/6 matched, HLA-A,-B,-C,-DRB1 allele 8/8 matched and HIM-A ,-B ,-C ,- DRB1 ,-DQBI allele10/10 matched unrelated marrow donor in a pool of 248 978 donors from CMDP were 0. 358 1,0. 274 9, and 0. 234 7 ,respectively. Based on the geographical region the Chinese can be classified into Northern Chinese （NCH） and Southern Chinese （SCH）. The probability of finding 6/6,8/8, and 10/10 matched donor in NCH and SCH were 0. 240 5 vs 0. 338 3,0. 180 7 vs 0. 262 8, and 0. 155 0 vs 0. 222 5, respectively. The NCH showed a higher genetic variation than the SCH. Conclusion The donors in registry of CMDP could be derived into two genetically distinct Northern and Southern groups. Selective recruitment of donors from certain geographical region may increase the probability of finding HLA-matched donor.