4-氨基苯甲酸的合成工艺研究

Study on the synthesis of 4-amino benzoic acid

以苯胺为原料,经酰基化、碘仿两步反应合成得到了目标产物4-氨基苯甲酸,并采用IR、1H NMR和13C NMR对产物结构进行了表征。探讨了酰基化反应时催化剂AlCl3用量、反应温度和反应时间对4-氨基苯乙酮产率的影响,以及碘仿反应中反应温度、反应时间和滴加4-氨基苯乙酮速率对产物产率的影响。在最佳合成条件下,4-氨基苯甲酸的产率可达94.0%。

The target compound 4 - amino benzoic acid was synthesized through acylation and iodoformation reactions with aniline as raw material. It was characterized by IR, 1H NMR and 13C NMR techniques. The influences of dosage of catalyst AICI3 , reaction temperature and reaction time on the yield of intermediate 4 - amino acetophenone were investigated in the acylation reaction. The effects of reaction temperature, reaction time and dropwise rate of 4 - amino acetophenone on the yield of 4 - amino benzoic acid were studied in the iodoformation reaction process. The yield of 4 - amino benzoic acid was 94.0% under the optimal conditions.