经尿道电切术联合吡柔比星膀胱灌注治疗腺性膀胱炎的疗效研究

Transurethral electroresection combined with bladder irrigation with pirarubicin for cystitis glandularis

目的探讨经尿道等离子电切术术后给予吡柔比星膀胱灌注治疗腺性膀胱炎的临床疗效。方法选取我院2009年1月～2012年10月诊治的腺性膀胱炎患者85例,随机分成两组,所有患者均接受经尿道等离子电切术,观察组术后联合给予吡柔比星膀胱灌注,对照组仅给予常规术后处理,观察两组临床疗效、术后一年复发率及不良反应。结果观察组的临床总有效率92.00%,显著高于对照组(65.71%),差异有统计学意义(P<0.05);观察组术后出现血尿、膀胱刺激征等不良反应发生率高于对照组,差异有显著性(P<0.05),而两组排尿困难和尿外渗等并发症发生率无统计学差异(P>0.05)。随访1年,观察组治愈率为86.00%,复发率为14.00%,均明显低于对照组(P<0.05),所有患者均未发现癌变病例。结论经尿道等离子电切术与吡柔比星膀胱灌注治疗腺性膀胱炎的疗效显著,复发率低,安全性高,但术后血尿和膀胱刺激征发生率较高。

Objective To investigate the efficacy of transurethral resection using bipolar plasma kinetic technique combined with bladder irrigation with pirarubicin for cystitis glandular.Methods All of 85 patients were randomly selected and divided into two groups.All of the patients were treated with transurethral resection using bipolar plasma kinetic technique.The observation groups were combined with intravesical irrigation of pirarubicin.The efficacy,recurrence rate and side effect were analyzed in the two groups.Results The Clinical total effective rate in observation groups（92.00%） was significance higher than control groups（P〈0.05）.The incidence of bladder irritation and hematuria in the two groups were significance difference（P〈0.05）.The complication rate of dysuria and urine leakage were in significance difference in the two groups（P〈0.05）.Follow up for 1 year,the curative rate and recurrence rate in observation groups（86.00% and 14.00%） was significance lower than control groups（P〈0.05）.Conclusion Transurethral electroresection combined with bladder irrigation with pirarubicin for cystitis glandular has well effec tive,high safety and low recurrence rate,but the side effects of bladder irritation and hematuria was obvious.