肝细胞肝癌TACE术后血管改变研究进展

Research progress of vascular change after TACE in hepatocellular carcinoma

肝细胞肝癌死亡率很高,但多数病人在确诊时往往处于中晚期而丧失手术机会,许多研究报道经导管动脉化疗栓塞(TACE)治疗手术不可切除肝癌具有较好疗效,推荐TACE作为巴塞罗那临床肝癌分期(BCLC分期)B级肝细胞肝癌病人的标准治疗方案。但TACE难以完全栓塞肿瘤血供,TACE术后血流动力学改变和血管新生可以使肿瘤复发和转移。就肝细胞肝癌TACE术后血管改变特征、机制、诊疗方法以及该研究领域的新进展进行综述。

Mortality rate of hepatocellular carcinoma is high. The majority of the patients are diagnosed in advanced stage and lose surgical opportunities, Many studies have reported transcatheter arterial chemoembolizatiou （TACE） is an effective treatment for unresectable hepatocellular carcinoma, and recommended TACE as a standard treatment for hepatocellular carcinoma of Barcelona Clinical Liver Cancer staging （BCLC staging ） B. However, TACE can hardly fully embolize tumor blood supply, TACE postoperative hemodynamics and angiogenesis can induce tumor recurrence and metastasis. This paper reviewed characteristics of vascular changes, mechanisms, diagnosis and treatment methods, new progress in the field of hepatocellular carcinoma after TACE.