雷贝拉唑预防哮喘发作期激素治疗诱发消化道溃疡的疗效观察

Curative effect observation of rabeprazole on preventing digestive tract ulcer induced by acute exacerbation of asthma treated with glucocorticoid

目的观察雷贝拉唑预防支气管哮喘发作期糖皮质激素治疗诱发消化道溃疡的疗效。方法支气管哮喘急性发作期患者60例,随机分为治疗组(30例)和对照组(30例),对照组患者监测生命体征,吸氧,维持电解质酸碱平衡,同时给予注射用琥珀酸氢化可的松100mg加入5%葡萄糖100mL中,静脉滴注,2次/d;二羟丙茶碱0.25g加入5%葡萄糖100mL中,静脉滴注,2次/d;盐酸氨溴索葡萄糖注射液100mL,静脉滴注,2次/d;孢硫脒2g加入生理盐水100mL,静脉滴注,2次/d,以抗生素控制感染。治疗组患者口服雷贝拉唑10mg/d,1次/d,其他治疗同对照组。两组均治疗两周。治疗结束后通过观察患者临床症状积分、大便潜血实验及胃镜等指标评价两组并发消化道溃疡的发生率及不良反应。结果治疗组和对照组并发消化道溃疡的发生率分别为30%、60%,两组比较有统计学差异(P<0.05)。结论雷贝拉唑能够大大降低支气管哮喘急性发作期糖皮质激素诱发消化道溃疡的发生率。

Objective To observe the curative effect of Rabeprazole on preventing the digestive tract ulcer induced by acute exacerbation of bronchial asthma treated with glucocorticoid. Methods The patients with acute exacerbation of bronchial asthma （60 cases） were randomly divided into treatment （30 cases） and control （30 cases） groups. The patients in the control group were given with oxygen, maintained the electrolyte acid-base balance, and the vital signs were monitored. The patients were iv administered with succinate cortisone （100 mg added into 100 mL 5% glucose） and iv administered with diprophylline （0.25 g added into 100 mL 5% glucose） twice daily. The patients in the control group were iv administered with 100 mL ambroxol glucose injection and spore cefathiamidine （2 g added into 100 mL physiological saline）, twice daily, with antibiotics to control infection. The patients in the treatment group were po administered with Rabeprazole （10 mg/d）, once daily, and other treatments were the same as the control group. Two groups were treated for two weeks. The incidence of the digestive tract ulcer and its adverse reactions were evaluated by observing the clinical symptom score, fecal occult blood test, endoscopy, and other indicators after treatment. Results The incidence of the digestive tract ulcer in the treatment and control groups was 30% and 60%, respectively with significant differences （P 0.05）. Conclusion Rabeprazole could greatly reduce the incidence of the digestive tract ulcer induced by acute exacerbation of bronchial asthma treated with glucocorticoid.