摘要
采用少量多次给大鼠腹腔注射顺铂 (CP) 模型 ,观察经口给予水飞蓟素 (SB) 后血尿素氮(BUN) 、一氧化氮 (NO) 含量及丙二醛 (MDA) 形成、超氧化物歧化酶(SOD) 活性等指标的变化。结果发现 ,CP使 BUN含量升高的同时 ,可使 NO、MDA生成量增多 ;而 SOD活性无变化 ;SB可使 BUN、MDA含量及 NO含量降至对照组水平 ,同时可使 SOD活性明显升高 ,表明 SB可预防 CP所致的肾损害 ,其机理可能与 SB降低 NO生成量有直接的关系。另外 ,SB有一定的抗肿瘤作用 ,对 CP的抗癌活性无影响。
Effects of silybin(SB) on nephrotoxicity of cisplatin(CP) in rats and its antitumour activity in mice was studied.The results showed that nephrotoxicity of CP in rats as measured by increase of renal cortex molondialdehyde(MDA),nitric oxide(NO) content and blood urea nitrogen(BUN) level was significantly alleviated by SB,the antitumour activity of CP,as assayed by the rate of Sarcoma 180 weight,was not reduced by SB treatment.It is concluded that SB may protect kidney against CP-induced nephrotoxicity in rats without interfering with its antitumour activity in mice.
出处
《辽宁中医杂志》
CAS
北大核心
2000年第7期332-333,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
辽宁省教委科研基金资助!(980 42 110 2 6 )
关键词
水飞蓟素
顺铂
肾毒性
氧化应激
一氧化氮
silybin(SB)
cisplatin(CP)
nephrotoxicity
oxidative stress
nitric oxide(NO)
