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尿激酶与重组组织型纤溶酶原激活剂静脉溶栓治疗急性心肌梗死的疗效比较 被引量:1

The comparison of the effect of UK and rt-PA intravenous thrombolytic therapy for acute myocardial infarc-tion
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摘要 目的 比较尿激酶(UK)与重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗急性心肌梗死的效果.方法 急性心肌梗死患者72例,借助SAS统计分析系统,按随机数字表法分为rt-PA组和UK组,每组36例.记录两组患者冠脉血管再通率、出血事件、不良心血管事件和病死率,并测定两组患者的肌钙蛋白T(cTnT).结果 rt-PA组患者溶栓开始后0.5h、1h、2h冠脉血管再通率均显著高于对照组,差异有统计学意义(x2 =7.32、6.12、5.81,均P<0.05).rt-PA组出血事件3例、病死2例,UK组出血事件5例、病死3例,差异无统计学意义(x2=1.22,均P>0.05).rt-PA组共出现不良心血管事件6例,对照组14例(x2=4.56,P<0.05).rt-PA组病死2例,UK组死亡3例,两组病死率差异无统计学意义(x2=0.40,P>0.05).两组患者cTnT在入院6h、12h时均较入院时有显著升高(t=6.67、6.30、4.11、4.22、4.40,均P<0.05),两组比较,rtPA组在入院6h、12 h时cTnT显著低于UK组(t=5.92、6.61,均P<0.05).结论 相比UK,rt-PA治疗急性心肌梗死再通率高,不良事件少,心肌损伤小,值得临床推广应用. Objective To compare the clinical effect of UK and rt-PA intravenous thrombolytic therapy for acute myocardial infarction. Methods By SAS statistical analysis system,72 patients with acute myocardial infarctionwere randomly divided into rt-PA group and UK group, each group had 36 cases. The coronary artery recanalization rate, bleeding events, adverse cardiovascular events, mortality, and cardiac, troponin T (eTnT) level were recorded. Results In rt-PA group,0.5h, 1 h,2h after the start of thrombolytic therapy, the coronary artery recanalization rate was significantly higher than that in the control group, the difference was statistically significant (X2 = 7.32,6.12, 5. 81 ,all P 〈0.05). In rt-PA group,3 cases had bleeding events ,2 cases died,and in UK group,5 cases had bleeding events ,3 eases died,, there was no statistically significant difference between the two groups ( X2 = 1.22, P 〉 0.05 ). In rt-PA group, there were 6 cases with adverse cardiovascular events, 14 cases in the control group, the difference was statistically significant (X2 = 4.56 ,P 〈 O. 05 ). 2 cases died in rt-PA group, 3 cases died in UK group, the mortality between the two groups had no statistically significant difference (P 〉 0.05 ). The cTnT level in the hospital 6h, 12h was significantly higher than admission in two groups ( t = 6.67,6.30,4.11,4.22,4.40, all P 〈 0.05 ). In rt-PA group,eTnT level in the hospital 6h, 12h was significantly lower than that in UK group (t = 5.92,6.61, all P 〈 0.05 ). Conclusion Compared with UK, rt-PA in the treatment of acute myocardial infarction can increase recanali- zation rate, decrease adverse events and myocardial injury,it is worthy of clinical application.
作者 徐冬梅 李琼
出处 《中国基层医药》 CAS 2013年第20期3111-3113,共3页 Chinese Journal of Primary Medicine and Pharmacy
关键词 心肌梗死 尿纤溶酶原激活物 重组酶类 血栓溶解疗法 Myocardial infarction Urinary plasminogen activator Recombinases Thrombolytic therapy
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