摘要
目的 研究多种性传播疾病 (sexuallytransmitteddisease,STD)病原体感染后人体的细胞免疫特征。 方法 通过流式细胞仪 ,运用标有异硫氰酸荧光素 (FITC)或藻红蛋白 (PE)的CD单抗分析 6 7例单一STD、6 5例STD多重感染者和 2 0名正常人的外周血T淋巴细胞亚群。结果 单一STD及STD多重感染者的外周血CD4+、CD8+及CD4+/CD8+比值之间在统计学上无显著性差异 (P >0 .0 5 ) ;STD多重感染者的CD4+、CD4+/CD8+的值低于正常 (P <0 .0 1)。
Purpose To study the characteristics of cellular immunity in patients with multiple sexually transmitted disease(STDs). Methods 67 patients with single STD,65 patients with multiple STDs and 20 normal controls were included in the study. Monoclonal antibodies of CD labeled with either FITC or PE were used on flow cytometry to detect peripheral blood lymphocyte immunophenotypes. Results There was no significantly difference between patients with single STD and those with multiple STDs concerning the level of CD4 +,CD8 + and CD4 +/CD8 +( P >0.05).The levels of CD4 + and CD4 +/CD8 + in the multiple STD group is significantly lower than that of normal controls( P <0.01). Conclusions Multiple STD pathogen infections may induce the decrease of cellular immunlity.
出处
《上海医科大学学报》
CSCD
2000年第5期382-383,共2页
Journal of Fudan University(Medical Science)
关键词
性传播疾病
多重感染
免疫表型
T淋巴细胞亚群
sexually transmitted disease
multiple infection
T- lymphocyte
immunophenotype