普罗布考治疗高血脂非增生型糖尿病视网膜病变的效果

Effect of Probucolin in the treatment of hyperlipemia nonproliferating diabetic retinopathy

目的探究普罗布考治疗高血脂非增生型糖尿病视网膜病变的临床疗效。方法对我院2011年9月～2012年9月临床确诊为高血脂非增生型糖尿病视网膜病变的患者50例100只眼，进行治疗。把患者进行随机平均分组，分为治疗组和对照组，每组25例患者50只眼。对两组患者进行同样的饮食、运动指导，并服用降糖药或者注射胰岛素，来控制血糖、血压，在此基础上对治疗组的患者使用普罗布考进行治疗，而对照组的患者只口服阿托伐他汀。对患者进行长期的治疗，观察其各项指标，进行分析。结果治疗组与对照组患者的微动脉瘤，相比治疗前都有减轻，总有效率分别为68．26％，34．45％，两组相比差异具有统计学意义（P〈0．05）。治疗组与对照组在治疗后视力回升的总有效率分别为45．28％，42．36％，两组相比差异无统计学意义（P〉0．05）。两组患者在治疗后黄斑水肿例数相对于治疗前有明显减少，差异具有统计学意义（P〈0．05）。在治疗后，患者的甘油三酯、低密度脂蛋白胆固醇、总胆固醇都有明显下降，而且治疗组的8-羟基脱氧鸟苷相对与对照组更低。结论使用普罗布考治疗高血脂非增生型糖尿病视网膜病变能够降低患者的血脂、恢复患者的视力、还能有效的减轻黄斑水肿的情况，是值得临床应用推广的方法。

Objective To explore the clinical curative effect of probucolin in the treatment of hyperlipemia nonproliferating diabetic retinopathy（DR）. Methods 100 eyes of 50 patients clinical diagnosed hyperlipemia nonproliferating diabetic retinopathy（DR） in our hospital from September 2011 to September 2012 were treated. The patients were randomly and equally divided into two groups, namely the treatment group and the control group, each group had 50 eyes of 25 patients.The patients of two groups were given the same diet and exercise guidance,and taken hypoglycemic drugs or injected insulin to control the blood sugar and blood pressure.On the basis,the patients in the treatment group were treated with probucol,while the patients in the control group only received atorvastatin.The patients were given long-term treatment,and the various indicators were observed and analyzed. Results Compared with before treatment,the microaneurysm of patients in the treatment group and the control group reduced, and the total effective rate was 68.26%,34.45% respectively,the difference was statistically significant（P 〈 0.05）.The total effective rate of vision upswing after treatment in the treatment group and the control group was 45.28%,42.36% respectively,and the difference was not statistically significant（P 〉 0.05）.Compared with before treatment,the number of macular edema after treatment in two groups reduced obviously, and the difference was statistically significant（P 〈 0.05）.The triglyceride, low density lipoprotein cholesterol and total cholesterol of patients after treatment decreased significantly, and the 8-hydroxydeoxyguanosine of the treatment group was lower than that of the control group. Conclusion Probucolin for hyperlipemia nonproliferating diabetic retinopathy（DR） can reduce blood lipid,recover vision,effectively reduce macular edema,and is worthy of clinical promotion and application.